Measurement of tumor blood flow using dynamic contrast-enhanced magnetic resonance imaging and deconvolution analysis: a preliminary study in musculoskeletal tumors
| Autor: | Yoshifumi Sugawara, Teruhito Mochizuki, Hitoshi Miki, Kenshi Sakayama, Keiichi Kikuchi, Tatsuhiko Miyazaki, Makoto Kajihara, Kenya Murase |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Adolescent Poor responder Gadolinium chemistry.chemical_element Contrast Media Bone Neoplasms Nuclear magnetic resonance In vivo Medicine Humans Radiology Nuclear Medicine and imaging Aged Aged 80 and over Muscle Neoplasms medicine.diagnostic_test business.industry Deconvolution analysis Magnetic resonance imaging Blood flow Middle Aged Magnetic Resonance Imaging Dynamic contrast Linear relationship chemistry Regional Blood Flow Female business Nuclear medicine |
| Zdroj: | Journal of computer assisted tomography. 30(6) |
| ISSN: | 0363-8715 |
| Popis: | Objective: To measure tumor blood flow (TBF) using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods: A DCE-MRI was performed using inversion recovery-preparation fast-field echo sequences. Dynamic data were obtained every 3.2 seconds for 2 minutes, immediately after gadolinium injection. In 14 patients with malignant musculoskeletal tumors, TBF maps were generated pixel-by-pixel by deconvolution analysis. For preclinical studies, muscle blood flow in 5 volunteers and signal intensities of different gadolinium concentrations were measured. Results: There was a good linear relationship between signal intensities and gadolinium concentrations (r = 0.989, P < 0.001, at gadolinium concentrations ≤2 mmol/L). The average value of muscle blood flow in volunteers was 11.1 + 2.7 mL·100 mL -1 ·min -1 . In 14 patients with musculoskeletal tumors, TBF showed wide variances: the lowest of 9.6 mL·100 mL -1 ·min -1 in liposarcoma and the highest of 182.0 mL·100 mL -1 ·min -1 in osteosarcoma. After chemotherapy, the TBF values (7.9, 11.0, and 11.7 mL· 100 mL -1 ·min -1 ) in the good responders were lower than those (26.8, 31.0, and 62.4 mL·100 mL -1 ·min -1 ) in the poor responders. Conclusions: A functional map of TBF generated by DCE-MRI and deconvolution analysis would be a promising tool for evaluating tumor blood flow in vivo. |
| Databáze: | OpenAIRE |
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