Dose-dependent suppression of tea catechins with a galloyl moiety on postprandial hypertriglyceridemia in rats
| Autor: | Ayumu Nozawa, Takami Kakuda, Makoto Kobayashi, Yuko M. Sagesaka, Yuko Suzuki, Tomonori Unno |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Absorption (skin) Fatty Acids Nonesterified complex mixtures Applied Microbiology and Biotechnology Biochemistry Catechin Analytical Chemistry chemistry.chemical_compound Internal medicine medicine Moiety Animals Rats Wistar Molecular Biology Triglycerides Hypertriglyceridemia Dose-Response Relationship Drug Tea Chemistry Organic Chemistry food and beverages General Medicine Gallate medicine.disease Postprandial Period Small intestine Rats Dose–response relationship Endocrinology Postprandial medicine.anatomical_structure lipids (amino acids peptides and proteins) Biotechnology |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 69(7) |
| ISSN: | 0916-8451 |
| Popis: | Tea has long been believed to be a healthy beverage, and its beneficial effects are almost all attributed to catechins. The effect of catechins on postprandial hypertriglyceridemia in rats was investigated in this study. A lipid emulsion administered orally to rats with (-)-epigallocatechin gallate at a dose of 100 mg/kg resulted in the increase in plasma triacylglycerol being significantly inhibited after 1 and 2 h compared to the case without (-)-epigallocatechin gallate. The effect of (-)-epigallocatechin was weaker than that of (-)-epigallocatechin gallate. A tea extract (THEA-FLAN 90S), mainly composed of catechins with a galloyl moiety, dose-dependently suppressed postprandial triacylglycerol after the administration of a lipid emulsion at doses of 50-200 mg/kg. The administration of the tea extract alone at a dose of 200 mg/kg had no effect on the plasma triacylglycerol level. These results strongly suggest that catechins with a galloyl moiety would be promising agents for suppressing dietary fat absorption through the small intestine. |
| Databáze: | OpenAIRE |
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