Behavioral and neural markers of cigarette-craving regulation in young-adult smokers during abstinence and after smoking
| Autor: | Dara G. Ghahremani, Edythe D. London, Paul Faulkner, Chelsea M. Cox |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Adolescent medicine.medical_treatment media_common.quotation_subject Craving Context (language use) Medical and Health Sciences Article 050105 experimental psychology Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans 0501 psychology and cognitive sciences Prefrontal cortex media_common Psychiatry Pharmacology Brain Mapping Smokers Psychology and Cognitive Sciences Smoking 05 social sciences Ventral striatum Cognition Abstinence Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Imagination Smoking cessation Female Orbitofrontal cortex medicine.symptom Psychology Photic Stimulation 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 43, iss 7 |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/s41386-018-0019-7 |
| Popis: | Cigarette craving contributes substantially to the maintenance of tobacco use disorder. Behavioral strategies to regulate craving may facilitate smoking cessation but remain underexplored. We adapted an emotion-regulation strategy, using proximal/distal self-positioning, to the context of cigarette craving to examine craving regulation in 42, daily smokers (18-25 years old). After overnight abstinence from smoking, before and after smoking their first cigarette of the day, participants viewed videos of natural scenes presenting young adults who were either smoking cigarettes ("smoke") or not ("non-smoke"). Before each video, participants were instructed to imagine themselves either immersed in the scene ("close") or distanced from it ("far"). They rated their craving after each video. Task-based fMRI data are presented for a subsample of participants (N = 21). We found main effects of smoking, instruction, and video type on craving-lower ratings after smoking than before, following the "far" vs. "close" instructions, and when viewing non-smoke vs. smoke videos. Before smoking, "smoke" vs. "non-smoke" videos elicited activation in, orbitofrontal cortex, anterior cingulate, lateral parietal cortex, mid-occipital cortex, ventral striatum, dorsal caudate, and midbrain. Smoking reduced activation in anterior cingulate, left inferior frontal gyrus, and bilateral temporal poles. Activation was reduced in the ventral striatum and medial prefrontal cortex after the "far" vs. the "close" instruction, suggesting less engagement with the stimuli during distancing. The results indicate that proximal/distal regulation strategies impact cue-elicited craving, potentially via downregulation of the ventral striatum and medial prefrontal cortex, and that smoking during abstinence may increase cognitive control capacity during craving regulation. |
| Databáze: | OpenAIRE |
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