The Constituents of Michelia compressa var. formosana and Their Bioactivities
| Autor: | Chia Che Wu, Guan-Jhong Huang, Yu Fon Chen, Shin-Hun Juang, Hui Ting Chang, Yu Yi Chan, Yu Ren Liao, Tian Shung Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Aporphines
Cell Survival Stereochemistry Anti-Inflammatory Agents Antineoplastic Agents macrophage Biology Nitric Oxide Jurkat cells Magnoliaceae Article Catalysis Inorganic Chemistry lcsh:Chemistry Jurkat Cells Cell Line Tumor Michelia formosana NO inhibition cytotoxicity medicine Carcinoma Humans Physical and Theoretical Chemistry Fibrosarcoma Cytotoxicity Molecular Biology lcsh:QH301-705.5 Spectroscopy Traditional medicine Plant Extracts Organic Chemistry Correction Liriodenine General Medicine medicine.disease Computer Science Applications Phytochemical Nasopharyngeal carcinoma lcsh:Biology (General) lcsh:QD1-999 HT1080 Drug Screening Assays Antitumor |
| Zdroj: | International Journal of Molecular Sciences, Vol 15, Iss 6, Pp 10926-10935 (2014) International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 15; Issue 6; Pages: 10926-10935 |
| ISSN: | 1422-0067 |
| Popis: | Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7–3.68 μM. |
| Databáze: | OpenAIRE |
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