Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan
| Autor: | Yuh Ling Sheu, Shing Yaw Wang, Ray H. Liu, Hsin Pei Tang, Yi-Chun Yeh, Jih-Heng Li, Wei Chiao Chang, Tze Chun Tang, Hsin Ya Lee |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Methadone maintenance medicine.medical_specialty ATP Binding Cassette Transporter Subfamily B Article Subject Taiwan lcsh:Medicine HIV Infections Pilot Projects Disease CYP2C19 General Biochemistry Genetics and Molecular Biology Opiate Substitution Treatment medicine Humans ATP Binding Cassette Transporter Subfamily B Member 1 Precision Medicine Psychiatry Alleles General Immunology and Microbiology Heroin Dependence business.industry lcsh:R General Medicine Middle Aged medicine.disease Precision medicine Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP2B6 Treatment Outcome Emergency medicine Coinfection Female Aryl Hydrocarbon Hydroxylases Personalized medicine business Methadone Research Article medicine.drug |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2013 (2013) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2013/741403 |
| Popis: | This pilot study simultaneously evaluated the effects of various factors, including genetic variations ofCYP2B6,CYP2C19, andABCB1, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the methadone maintenance treatment program (MMTP) in Taiwan. A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program. The results demonstrated that the methadone maintenance dose,CYP2B6785G allele, andABCB12677T allele have positive effects on the methadone plasma concentration. In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment. Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use. The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP. |
| Databáze: | OpenAIRE |
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