Investigation of SARS-CoV-2 infection in dogs and cats of humans diagnosed with COVID-19 in Rio de Janeiro, Brazil
| Autor: | Maria Lopes Corrêa, Isabela Maria da Silva Antonio, Michele Fernanda Borges da Silva, Artur Augusto Velho Mendes Junior, Alex Pauvolid-Corrêa, Fernando Couto Motta, Lucas Oliveira Keidel, Patrícia Brasil, Isabella Campos Vargas de Moraes, Alice Sampaio Barreto da Rocha, Paola Cristina Resende, Sandro Antonio Pereira, Thiago das Chagas Souza, Shanna Araujo Dos Santos, Anielle de Pina Costa, Isabella Dib Ferreira Gremião, Ezequias Batista Martins, Guilherme Amaral Calvet, Maria Ogrzewalska, Rodrigo Caldas Menezes, Renato Orsini Ornellas, Marilda Mendonça Siqueira, Lusiele Guaraldo, Ana Beatriz Machado Lima, Wagner de Souza Tassinari |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
RNA viruses
0301 basic medicine Viral Diseases Pulmonology Coronaviruses Artificial Gene Amplification and Extension Antibodies Viral Cat Diseases Polymerase Chain Reaction Persistence (computer science) Medical Conditions 0302 clinical medicine Epidemiology Prevalence Medicine Dog Diseases Longitudinal Studies 030212 general & internal medicine Pathology and laboratory medicine Virus Testing Mammals Multidisciplinary CATS biology Pets and Companion Animals virus diseases Eukaryota Pets Medical microbiology Infectious Diseases Neutering Animals Domestic Viruses Vertebrates SARS CoV 2 Pathogens Antibody Brazil Research Article medicine.medical_specialty SARS coronavirus Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Science Research and Analysis Methods Microbiology Respiratory Disorders 03 medical and health sciences Dogs Plaque reduction neutralization test Diagnostic Medicine Internal medicine Animals Molecular Biology Techniques Molecular Biology Medicine and health sciences Biology and life sciences SARS-CoV-2 business.industry Organisms Viral pathogens COVID-19 Covid 19 Reverse Transcriptase-Polymerase Chain Reaction Antibodies Neutralizing Microbial pathogens 030104 developmental biology Amniotes Respiratory Infections Cats biology.protein business Zoology |
| Zdroj: | PLoS ONE, Vol 16, Iss 4, p e0250853 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Infection by SARS-CoV-2 in domestic animals has been related to close contact with humans diagnosed with COVID-19. Objectives: To assess the exposure, infection, and persistence by SARS-CoV-2 of dogs and cats living in the same households of humans that tested positive for SARS-CoV-2, and to investigate clinical and laboratory alterations associated with animal infection. Methods Animals living with COVID-19 patients were longitudinally followed and had nasopharyngeal/oropharyngeal and rectal swabs collected and tested for SARS-CoV-2. Additionally, blood samples were collected for laboratory analysis, and plaque reduction neutralization test (PRNT90) to investigate specific SARS-CoV-2 antibodies. Results Between May and October 2020, 39 pets (29 dogs and 10 cats) of 21 patients were investigated. Nine dogs (31%) and four cats (40%) from 10 (47.6%) households were infected with or seropositive for SARS-CoV-2. Animals tested positive from 11 to 51 days after the human index COVID-19 case onset of symptoms. Three dogs tested positive twice within 14, 30, and 31 days apart. SARS-CoV-2 neutralizing antibodies were detected in one dog (3.4%) and two cats (20%). In this study, six out of thirteen animals either infected with or seropositive for SARS-CoV-2 have developed mild but reversible signs of the disease. Using logistic regression analysis, neutering, and sharing bed with the ill owner were associated with pet infection. Conclusions The presence and persistence of SARS-CoV-2 infection have been identified in dogs and cats from households with human COVID-19 cases in Rio de Janeiro, Brazil. People with COVID-19 should avoid close contact with their pets during the time of their illness. |
| Databáze: | OpenAIRE |
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