Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults
| Autor: | Ayman Barghash, Amany K. Elshorbagy, Hagar Elkafrawy, Iman Samy Dessouky, C. A. P. Turner, Radwa A. Mehanna, Helga Refsum, Fredrik Jernerén, Fayrouz Ali |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Clinical Biochemistry Cystine Gene Expression Sulfur amino acids medicine.disease_cause Biochemistry Body Mass Index chemistry.chemical_compound BMI In vivo Adipocyte Internal medicine Extracellular medicine Adipocytes Humans Sulfhydryl Compounds Obesity Cells Cultured Adiposity Adipogenesis Organic Chemistry Biochemistry and Molecular Biology Cell Differentiation Metabolism PPAR gamma Endocrinology chemistry Adipose Tissue Body Composition Female Original Article Amino Acids Essential Oxidative stress Biokemi och molekylärbiologi Cysteine |
| Zdroj: | Amino Acids |
| ISSN: | 0939-4451 |
| Popis: | Plasma cysteine is associated with human obesity, but it is unknown whether this is mediated by reduced, disulfide (cystine and mixed-disulfides) or protein-bound (bCys) fractions. We investigated which cysteine fractions are associated with adiposity in vivo and if a relevant fraction influences human adipogenesis in vitro. In the current study, plasma cysteine fractions were correlated with body fat mass in 35 adults. Strong positive correlations with fat mass were observed for cystine and mixed disulfides (r ≥ 0.61, P PPARG2 (to sixfold), PPARG1, PLIN1, SCD1 and CDO1 (P = 0.042– P |
| Databáze: | OpenAIRE |
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