PARATHYROID HORMONE AND 25-HYDROXYVITAMIN D LEVELS IN GLUCOCORTICOID-TREATED PATIENTS
| Autor: | Robert M. Neer, Gino V. Segre, David M. Slovik, M. B. Clark, John T. Potts, F. C. Lowell, J. L. Ohman |
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| Rok vydání: | 1980 |
| Předmět: |
Adult
Male medicine.medical_specialty Bone disease Endocrinology Diabetes and Metabolism Parathyroid hormone Endocrinology Internal medicine medicine Vitamin D and neurology Humans Asthmatic patient Glucocorticoids Hydroxycholecalciferols business.industry medicine.disease Disease control Asthma Parathyroid Hormone Glucocorticoid therapy Female business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Clinical Endocrinology. 12:243-248 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.1980.tb02706.x |
| Popis: | Abnormalities in parathyroid hormone (PTH) secretion or vitamin D action or metabolism have been suggested as pathogenetic factors in the bone disease associated with chronic glucocorticoid therapy. We have found normal plasma PTH values in forty-eight adult asthmatic patients on chronic glucocorticoid therapy, twelve asthmatics treated without glucocorticoids and ten adults on short-term, high-dose glucocorticoid therapy for non-asthmatic illnesses. The mean serum 25-OHD level in the glucocorticoid-treated asthmatics was not significantly different from a disease control group of asthmatic patients not on glucocorticoids, but nine such patients had abnormally low 25-OHD levels. Our results indicate that in asthmatic patients on chronic glucocorticoid therapy: (1) PTH and 25-OHD values are usually normal regardless of dose or duration of therapy and (2) there is a subset of patients with low 25-OHD values which may reflect unusual sensitivity to glucocorticoids. |
| Databáze: | OpenAIRE |
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