Genetics of schizophrenia in the South African Xhosa
| Autor: | Adele Pretorius, R. A. Gibbs, Adam Baldinger, Odwa A. Ntola, Sibonile G. Mqulwana, Goodman Sibeko, R. C. Gur, Dan J. Stein, Mohamed Nagdee, Viktoriya Korchina, Kim M. Fader, Mary Claire King, Michael M. Mndini, Howard Andrews, Linda Ngqengelele, Emily A. Willoughby, Donna M. Muzny, Suleyman Gulsuner, M. Feng, Rajkumar Ramesar, C. van der Merwe, Ezra Susser, Megan Malan, Jon McClellan, Lerato Majara, Zukiswa Zingela, Tom Walsh, Silvia Casadei |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Bipolar Disorder Schizophrenia (object-oriented programming) Dopamine Glutamine Population Complex disease Biology Synaptic Transmission Article South Africa Sex Factors Genetic variation Neural Pathways Humans Autistic Disorder education Gene gamma-Aminobutyric Acid Genetics education.field_of_study Multidisciplinary Age Factors Genetic Variation language.human_language Synaptic plasticity Mutation Synapses language Schizophrenia Human genome Female Xhosa |
| Zdroj: | Science |
| ISSN: | 1095-9203 |
| Popis: | African schizophrenia genetic variants The genetics of schizophrenia have predominately been studied in populations of European and Asian descent. However, studies in Africans, who host the greatest degree of human genetic diversity, have lagged. Examining the exomes of more than 1800 Xhosa individuals from South Africa, about half of which have been diagnosed with schizophrenia, Gulsuner et al. identified both rare and common genetic variants associated with the disease. They found that the genetic architecture of schizophrenia in Africans generally reflects that of Europeans but that the greater genetic variation in Africa provides more power to detect relationships of genes to phenotypes. Science , this issue p. 569 |
| Databáze: | OpenAIRE |
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