Neural stem cells in the mammalian eye: types and regulation
| Autor: | Xing Zhao, Ani V. Das, Sumitra Bhattacharya, Jackson James, Iqbal Ahmad |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Central Nervous System
Cellular differentiation Receptors Cell Surface Biology Eye Ligands Models Biological Retina Neurosphere Animals Humans Pigment Epithelium of Eye Mammals Induced stem cells Gene Expression Profiling Stem Cells Ciliary Body Cell Differentiation Cell Biology Neural stem cell Cell biology Neuroepithelial cell Stem cell Biomarkers Cell Division Signal Transduction Transcription Factors Developmental Biology Adult stem cell Cerebral organoid |
| Zdroj: | Seminars in Cell & Developmental Biology. 15:53-62 |
| ISSN: | 1084-9521 |
| DOI: | 10.1016/j.semcdb.2003.09.003 |
| Popis: | Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors. |
| Databáze: | OpenAIRE |
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