High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma: Part 1: MRI vs. histopathology
| Autor: | Petra Temming, Selma Sirin, Markus Holdt, Norbert Bornfeld, Bernd Schweiger, Marc Schlamann, Michael M. Schuendeln, Klaus A. Metz, Sophia L. Goericke |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Retinal Neoplasms Enucleation Transducers Medizin Risk Assessment Sensitivity and Specificity medicine Humans Radiology Nuclear Medicine and imaging Neuroradiology medicine.diagnostic_test Retinoblastoma business.industry Infant Reproducibility of Results Retrospective cohort study Magnetic resonance imaging Gold standard (test) Equipment Design medicine.disease Image Enhancement Magnetic Resonance Imaging eye diseases Equipment Failure Analysis Optic nerve Histopathology Female Neurology (clinical) Radiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Neuroradiology. 57(8) |
| ISSN: | 1432-1920 |
| Popis: | INTRODUCTION A reliable detection of metastatic risk factors is important for children with retinoblastoma to choose the right therapeutic regimen. First studies using high-resolution magnetic resonance imaging (MRI) with orbit surface coils were promising. The aim of this study was therefore to evaluate the ability of high-resolution MRI to detect metastatic and especially advanced metastatic risk factors in a large group of children with retinoblastoma. METHODS One hundred forty-three consecutive children with retinoblastoma (148 enucleated eyes, 64 girls, 79 boys, mean age 19.7 ± 15.3) who received pretherapeutical high-resolution MRI with orbit surface coils on 1.5 T MR scanner systems between 2007 and 2012 and subsequent primary enucleation within 14 days were included in this retrospective study. Image analysis was performed by two neuroradiologists experienced in ocular imaging in consensus. Histopathology served as gold standard. RESULTS Sensitivity/specificity for the detection of metastatic risk factors using high-resolution MRI with orbit surface coils were 60 %/88.7 % for postlaminar optic nerve infiltration, 65.5 %/95.6 % for choroidal invasion, 100 %/99.3 % for scleral invasion, and 100 %/100 % for peribulbar fat invasion, respectively. The results increased for the detection of advanced metastatic risk factors, 81.8 %/89.1 % for deep postlaminar optic nerve infiltration, 70.6 %/97.6 % for massive choroidal invasion. CONCLUSIONS High-resolution MRI is clinically valuable for the detection of metastatic, especially of advanced metastatic risk factors in children with retinoblastoma. |
| Databáze: | OpenAIRE |
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