A Case of Histoplasma duboisii Brain Abscess and Review of the Literature
| Autor: | Landry Drogba, Doukoure Brahima, Landry M. Konan, Fassil B. Mesfin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Histoplasma duboisii Itraconazole Neurosurgery Infectious Disease chemical and pharmacologic phenomena capsulatum 030204 cardiovascular system & hematology complex mixtures Histoplasma capsulatum Histoplasmosis 03 medical and health sciences fluids and secretions 0302 clinical medicine parasitic diseases histoplasma capsulatum medicine duboisii histoplasma duboisii Brain abscess biology histoplasmosis business.industry General Engineering bacterial infections and mycoses medicine.disease biology.organism_classification brain abscess Fungal disease Neurology mycotic disease Vomiting Osteitis medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.6984 |
| Popis: | Histoplasmosis is a fungal disease caused by Histoplasma capsulatum var. capsulatum (Hcc) and H. capsulatum var. duboisii (Hcd). Central nervous system (CNS) involvement is rare. So far, the few cases reported having Histoplasmosis associated brain abscesses were caused by H. capsulatum var. capsulatum. Herein, we report a unique case of brain abscess caused by H. capsulatum var. duboisii occurring in a 42-year-old immunocompromised woman with HIV. Initially, she presented with hypothermia, vomiting, frontal headache, evolving over one month. She then progressed to have a generalized seizure. Brain MRI showed multifocal brain abscesses and a frontal osteitis. The frontal osteitis was biopsied and confirmed the diagnosis of H. capsulatum var. duboisii. She was successfully treated with liposomal amphotericin B (150 mg daily) for the first four weeks and itraconazole (200mg twice daily) for six months. |
| Databáze: | OpenAIRE |
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