Amino acid transporters revisited: New views in health and disease
| Autor: | Palanivel Kandasamy, Yoshikatsu Kanai, Gergely Gyimesi, Matthias A. Hediger |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
congenital hereditary and neonatal diseases and abnormalities Amino Acid Transport Systems Protein Conformation Longevity Biology Kidney Biochemistry Kidney Tubules Proximal 03 medical and health sciences Stress Physiological Humans Disease Amino Acids Intestinal Mucosa 610 Medicine & health Molecular Biology Amino Acid Metabolism Inborn Errors chemistry.chemical_classification Catabolism Autophagy Transporter Epithelial Cells Membrane transport Amino acid Transport protein 030104 developmental biology chemistry Cancer cell 570 Life sciences biology Intracellular |
| DOI: | 10.7892/boris.120389 |
| Popis: | Amino acid transporters (AATs) are membrane-bound transport proteins that mediate transfer of amino acids into and out of cells or cellular organelles. AATs have diverse functional roles ranging from neurotransmission to acid-base balance, intracellular energy metabolism, and anabolic and catabolic reactions. In cancer cells and diabetes, dysregulation of AATs leads to metabolic reprogramming, which changes intracellular amino acid levels, contributing to the pathogenesis of cancer, obesity and diabetes. Indeed, the neutral amino acid transporters (NATs) SLC7A5/LAT1 and SLC1A5/ASCT2 are likely involved in several human malignancies. However, a clinical therapy that directly targets AATs has not yet been developed. The purpose of this review is to highlight the structural and functional diversity of AATs, their diverse physiological roles in different tissues and organs, their wide-ranging implications in human diseases and the emerging strategies and tools that will be necessary to target AATs therapeutically. |
| Databáze: | OpenAIRE |
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