Serum 3α-androstanediol glucuronide measurements in children with congenital adrenal hyperplasia
| Autor: | Ali Süha Calikoglu, Şükrü Hatun, N. Yordam |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Urinary system Excretion chemistry.chemical_compound Endocrinology Internal medicine Hydroxyprogesterones medicine Humans Testosterone Congenital adrenal hyperplasia Androstenedione Adrenal Hyperplasia Congenital business.industry 17-alpha-Hydroxyprogesterone Infant Newborn Infant Dihydrotestosterone General Medicine 3α-Androstanediol medicine.disease Androstane-3 17-diol Cross-Sectional Studies chemistry Child Preschool Female Glucuronide business Follow-Up Studies medicine.drug |
| Zdroj: | European Journal of Endocrinology. 131:504-508 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1310504 |
| Popis: | Hatun Ş, Yordam N, Çalikoǧlu AS. Serum 3α-androstandiol glucuronide measurements in children with congenital adrenal hyperplasia. Eur J Endocrinol 1994;131:504–8. ISSN 0804–4643 To determine the value of 3α-androstanediol glucuronide (3-AG) measurements in children with congenital adrenal hyperplasia, we compared serum 3AG, 17-hydroxyprogesterone (17-OHP), androstenedione (A), testosterone (T) and dihydrotestosterone (DHT) levels and 24-h urinary 17-ketosteroid (17-KS) excretion in 42 female children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency, including 27 with the simple virilizing and 15 with the salt-losing form. Their mean age was 74.5 ±48.5 months (range, 6–194 months). Twenty-four-hour urinary 17-KS excretion and serum 3-AG, A, T, DHT and 17-OHP levels were measured in the patients. The values were less than the mean + 2 sd of the control group in 63%, 74%, 67%, 69%, 60% and 31% of the patients, respectively. Serum 3-AG levels correlated with 24-h urinary 17-KS excretion (r = 0.66) and plasma A (r = 0.80), 17-OHP (r = 0.56), T (r = 0.79) and DHT (r = 0.62) levels. We conclude that serum 3-AG is a useful metabolic index in the management of children with congenital adrenal hyperplasia. Şükrü Hatun, Türk-İş Blk, 274/7, Aydinlikevler, Ankara, Turkey |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|