Salicylic Acid Activates DNA Damage Responses to Potentiate Plant Immunity
| Autor: | Shunping Yan, Abdelaty Saleh, Wendy E. Durrant, Rajinikanth Mohan, Junqi Song, Wei Wang, Xinnian Dong, Jorge Marqués |
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| Rok vydání: | 2013 |
| Předmět: |
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Molecular DNA Repair DNA Plant DNA repair DNA damage Regulator Arabidopsis Cell Cycle Proteins Ataxia Telangiectasia Mutated Proteins Biology medicine.disease_cause Protein Structure Secondary Article chemistry.chemical_compound Immune system Plant Growth Regulators Gene expression medicine Plant Immunity Molecular Biology Mutation Arabidopsis Proteins fungi food and beverages Nuclear Proteins Cell Biology Protein Subunits chemistry Biochemistry Structural Homology Protein Multiprotein Complexes Salicylic Acid Salicylic acid DNA DNA Damage |
| Zdroj: | Molecular Cell. 52(4):602-610 |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/j.molcel.2013.09.019 |
| Popis: | DNA damage is normally detrimental to living organisms. Here we show that it can also serve as a signal to promote immune responses in plants. We found that the plant immune hormone salicylic acid (SA) can trigger DNA damage in the absence of a genotoxic agent. The DNA damage sensor proteins, RAD17 and ATR, are required for effective immune responses. These sensor proteins are negatively regulated by a key immune regulator SNI1 (suppressor of npr1-1, inducible 1), which we discovered as a missing subunit of the Structural Maintenance of Chromosome (SMC) 5/6 complex required for controlling DNA damage. Elevated DNA damage caused by the sni1 mutation or treatment with a DNA-damaging agent markedly enhances SA-mediated defense gene expression. Our study suggests that activation of DNA damage responses is an intrinsic component of the plant immune responses. |
| Databáze: | OpenAIRE |
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