Synuclein in cutaneous autonomic nerves
Autor: | Ningshan Wang, Christopher H. Gibbons, Roy Freeman, Jacob Lafo |
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Rok vydání: | 2013 |
Předmět: |
Male
Pathology medicine.medical_specialty Posture Statistics as Topic Adrenergic Sensory system Nerve fiber Biology Thigh Article Nerve Fibers Heart Rate medicine Humans Autonomic Pathways Aged Skin Neurologic Examination Cholinergic Fibers Respiration Parkinson Disease Middle Aged Sudomotor medicine.anatomical_structure Case-Control Studies alpha-Synuclein Biomarker (medicine) Female α synuclein Neurology (clinical) Nervous System Diseases |
Zdroj: | Neurology. 81:1604-1610 |
ISSN: | 1526-632X 0028-3878 |
Popis: | To develop a cutaneous biomarker for Parkinson disease (PD).Twenty patients with PD and 14 age- and sex-matched control subjects underwent examinations, autonomic testing, and skin biopsies at the distal leg, distal thigh, and proximal thigh. α-Synuclein deposition and the density of intraepidermal, sudomotor, and pilomotor nerve fibers were measured. α-Synuclein deposition was normalized to nerve fiber density (the α-synuclein ratio). Results were compared with examination scores and autonomic function testing.Patients with PD had a distal sensory and autonomic neuropathy characterized by loss of intraepidermal and pilomotor fibers (p0.05 vs controls, all sites) and morphologic changes to sudomotor nerve fibers. Patients with PD had greater α-synuclein deposition and higher α-synuclein ratios compared with controls within pilomotor nerves and sudomotor nerves (p0.01, all sites) but not sensory nerves. Higher α-synuclein ratios correlated with Hoehn and Yahr scores (r = 0.58-0.71, p0.01), with sympathetic adrenergic function (r = -0.40 to -0.66, p0.01), and with parasympathetic function (r = -0.66 to -0.77, p0.01).We conclude that α-synuclein deposition is increased in cutaneous sympathetic adrenergic and sympathetic cholinergic fibers but not sensory fibers of patients with PD. Higher α-synuclein deposition is associated with greater autonomic dysfunction and more advanced PD. These data suggest that measures of α-synuclein deposition in cutaneous autonomic nerves may be a useful biomarker in patients with PD. |
Databáze: | OpenAIRE |
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