Prognostic Value of Platelet to Lymphocyte Ratio in Sepsis: A Systematic Review and Meta-analysis

Autor: Gancheng Wang, Azam Mivefroshan, Shirin Yaghoobpoor, Shokoufeh Khanzadeh, Goli Siri, Farzad Rahmani, Samira Aleseidi
Rok vydání: 2022
Předmět:
Zdroj: BioMed Research International. 2022:1-11
ISSN: 2314-6141
2314-6133
DOI: 10.1155/2022/9056363
Popis: The goal of this study was to conduct a systematic review of the literature on the relationship between peripheral blood platelet to lymphocyte ratio (PLR) and mortality in sepsis and to integrate the findings in a meta-analysis. An electronic search of three main databases was performed: PubMed, Embase, and Scopus on 19 December 2021. Finally, 16 studies comprising 2403 septic patients, including 1249 survivors and 1154 nonsurvivors, were included in this meta-analysis. We found that PLR levels were significantly higher in nonsurvivors than in survivors (random effect model: SMD = 0.72 , 95% CI; 0.35–1.10, p < 0.001 ). However, significant heterogeneity was observed across the studies ( I 2 = 94.1 % , p < 0.01 ). So, we used random effect model in our meta-analysis. In the subgroup analysis, according to mortality time, patients deceased during one month after sepsis had elevated levels of PLR compared to survivors ( SMD = 1.03 , 95% CI = 0.15 -1.92, p = 0.22 ). However, in-hospital mortality was not associated with PLR level ( SMD = 0.41 , 95% CI = − 0.18 -0.99, p = 0.175 ). Our findings support PLR to be a promising biomarker that can be readily integrated into clinical settings to aid in the prediction and prevention of sepsis mortality.
Databáze: OpenAIRE
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