Somatosensory-motor cortex interactions measured using dual-site transcranial magnetic stimulation
| Autor: | Anne Weissbach, Matt J. N. Brown, Martje G. Pauly, Michael Vesia, Tobias Bäumer, Julianne Baarbé, Alexander Münchau, Robert Chen, Carolyn Gunraj |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Paired-pulse TMS medicine.medical_treatment Biophysics Dual-site TMS Somatosensory Stimulus (physiology) Somatosensory system Functional Laterality 050105 experimental psychology Dual site Lateralization of brain function lcsh:RC321-571 Young Adult 03 medical and health sciences 0302 clinical medicine Active contraction medicine Humans 0501 psychology and cognitive sciences Sensorimotor control lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Electromyography Chemistry General Neuroscience 05 social sciences Motor Cortex Neural Inhibition Somatosensory Cortex Evoked Potentials Motor Transcranial Magnetic Stimulation Transcranial magnetic stimulation medicine.anatomical_structure Motor TMS Female Neurology (clinical) Primary motor cortex Neuroscience 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Brain Stimulation, Vol 12, Iss 5, Pp 1229-1243 (2019) |
| Popis: | Background Dual-site transcranial magnetic stimulation (ds-TMS) is a neurophysiological technique to measure functional connectivity between cortical areas. Objective/Hypothesis To date, no study has used ds-TMS to investigate short intra-hemispheric interactions between the somatosensory areas and primary motor cortex (M1). Methods We examined somatosensory-M1 interactions in the left hemisphere in six experiments using ds-TMS. In Experiment 1 (n = 16), the effects of different conditioning stimulus (CS) intensities on somatosensory-M1 interactions were measured with 1 and 2.5 ms inter-stimulus intervals (ISIs). In Experiment 2 (n = 16), the time-course of somatosensoy-M1 interactions was studied using supra-threshold CS intensity at 6 different ISIs. In Experiment 3 (n = 16), the time-course of short-interval cortical inhibition (SICI) and effects of different CS intensities on SICI were measured similar to Experiments 1 and 2. Experiment 4 (n = 13) examined the effects of active contraction on SICI and somatosensory-M1 inhibition. Experiments 5 and 6 (n = 10) examined the interactions between SAI with either 1 ms SICI or somatosensory-M1 inhibition. Results Experiments 1 and 2 revealed reduced MEP amplitudes when applying somatosensory CS 1 ms prior to M1 TS with 140 and 160% CS intensities. Experiment 3 demonstrated that SICI at 1 and 2.5 ms did not correlate with somatosensory-M1 inhibition. Experiment 4 found that SICI but not somatosensory-M1 inhibition was abolished with active contraction. The results of Experiments 5–6 showed SAI was disinhibited in presence of somatosensory-M1 while SAI was increased in presence of SICI. Conclusion Collectively, the results support the notion that the somatosensory areas inhibit the ipsilateral M1 at very short latencies. |
| Databáze: | OpenAIRE |
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