Honokiol Is a Potential Therapeutic Agent and Has a Synergistic Effect With 5-FU in Human Urothelial Cell Carcinoma Cells
| Autor: | Hui-Chen Chung, Chung-Sheng Shi, Ying-Ray Lee, Kao Jean Huang, Yun-Ching Huang, Pei-Wen Zhao, Ming-Yang Lee, Shu-Hsin Chen, Yen-Chen Hsu |
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| Rok vydání: | 2019 |
| Předmět: |
Honokiol
Cancer Research Cell cycle checkpoint Cell Survival medicine.disease_cause Lignans 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Urothelial cell carcinoma Cell Line Tumor medicine Humans Cytotoxic T cell Cell Proliferation Caspase 3 Chemistry Biphenyl Compounds Cell Cycle Drug Synergism General Medicine Caspase 9 In vitro Gene Expression Regulation Neoplastic Urinary Bladder Neoplasms Oncology Apoptosis 030220 oncology & carcinogenesis Cancer research Fluorouracil Poly(ADP-ribose) Polymerases Growth inhibition Apoptosis Regulatory Proteins Carcinogenesis |
| Zdroj: | Anticancer Research. 39:6555-6565 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | BACKGROUND/AIM Honokiol is a biphenolic component of the bark of Magnolia, and has been shown to exert several activities, including anti-depressant, anti-emetic, anti-oxidative, anti-thrombotic, anti-angiogenesis, anti-anxiolytic, anti-inflammatory and anti-tumor effects. MATERIALS AND METHODS The anti-tumor activities of honokiol and its synergistic effect with 5-fluorouracil (5-FU) in human urothelial cell carcinoma (UCC) cells were investigated. RESULTS Honokiol significantly suppressed the proliferation of UCC cells in a dose- and time-dependent manner. Moreover, honokiol inhibited the tumorigenesis of UCC cells in vitro. In addition, honokiol induced cell cycle arrest at G0/G1 phase and caused apoptosis of UCC cells through the intrinsic pathway. Importantly, we demonstrated that honokiol potentiated the cytotoxic effect of 5-FU, and displayed a synergistic effect with 5-FU in UCC cells. CONCLUSION Honokiol causes growth inhibition, tumorigenesis suppression, cell cycle arrest, apoptosis, and importantly has a synergistic effect with 5-FU in human UCC cells. Therefore, this agent displays a therapeutic potential for treating human UCC. |
| Databáze: | OpenAIRE |
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