Normoxic polyacrylamide gel doped with iodine: response versus X-ray energy
| Autor: | Jérôme Gastaldo, Stéphanie Corde, Irène Troprès, Hélène Elleaume, Caroline Boudou, Laurent Lamalle, Günther Rucka, Albéric Sollier |
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| Přispěvatelé: | Serduc, Raphael, European Synchrotron Radiation Facility (ESRF), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), RMN biomédicale : de la cellule à l'homme (RBCH), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-DIR CENTRALE DU SSA-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de cancérologie et radiothérapie, CHU Grenoble |
| Rok vydání: | 2008 |
| Předmět: |
MESH: Radiation Dosage
MESH: Iodine MESH: Gels Polyacrylamide Acrylic Resins chemistry.chemical_element Linear energy transfer Iodine Radiation Dosage 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine MESH: Computer Simulation law MESH: Dose-Response Relationship Radiation MESH: Linear Energy Transfer Medicine Radiology Nuclear Medicine and imaging Computer Simulation Linear Energy Transfer Irradiation [SDV.IB] Life Sciences [q-bio]/Bioengineering MESH: Acrylic Resins Dosimeter business.industry Radiochemistry MESH: Models Chemical X-ray Dose-Response Relationship Radiation General Medicine Synchrotron Beamline chemistry Models Chemical 030220 oncology & carcinogenesis MESH: Synchrotrons [SDV.IB]Life Sciences [q-bio]/Bioengineering business Nuclear medicine Gels Synchrotrons |
| Zdroj: | European Journal of Radiology European Journal of Radiology, 2008, 68 (3 Suppl), pp.S118-20. ⟨10.1016/j.ejrad.2008.04.053⟩ European Journal of Radiology, Elsevier, 2008, 68 (3 Suppl), pp.S118-20. ⟨10.1016/j.ejrad.2008.04.053⟩ |
| ISSN: | 1872-7727 0720-048X |
| DOI: | 10.1016/j.ejrad.2008.04.053⟩ |
| Popis: | International audience; The basis of Synchrotron Stereotactic Radio-Therapy (SSRT) is the incorporation of high atomic number atoms (iodine, for example) into the tumour mass followed by an irradiation with a monochromatic, low energy, X-ray beam from a synchrotron source. The purpose of the present study was to determine whether polymer gel dosimetry could be used to measure the enhancement of absorbed energy induced by the iodine in the media. We have used a standard nPAG formulation, loaded with NaI and the irradiations were performed either with monochromatic X-rays at the ESRF medical beamline or with a conventional 6 MV X-ray beam from a linear accelerator at the Grenoble University Hospital. We observed sensitivity increase with iodine loaded gels irradiated at low energies, in good agreement with the theoretical iodine dose-enhancement. As expected, the response of the iodine-doped polymer gel was not increased after irradiation with mega-voltage X-rays. We demonstrate in this study that polymer gel dosimeters can be used for measuring dose-enhancement due to iodine presence in SSR treatment. |
| Databáze: | OpenAIRE |
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