Timing of Heparin and Perfusion Temperature During Procurement of Organs with Extracorporeal Support in Donors After Circulatory Determination of Death
| Autor: | Jeffrey D. Punch, Keith E. Cook, Candice M. Hall, Alvaro Rojas-Pena, Robert H. Bartlett, Juan D. Arenas |
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| Rok vydání: | 2011 |
| Předmět: |
Extracorporeal Circulation
medicine.medical_specialty Time Factors Swine medicine.medical_treatment Biomedical Engineering Biophysics Bioengineering Normal values FOS: Medical engineering Extracorporeal Biomaterials Internal medicine medicine Animals Humans Cardiopulmonary resuscitation Heparin business.industry Extracorporeal circulation Temperature 90399 Biomedical Engineering not elsewhere classified General Medicine Cardiopulmonary Resuscitation Tissue Donors Heart Arrest Death Perfusion Circulatory system Tissue and Organ Harvesting Cardiology Successful resuscitation business medicine.drug |
| Zdroj: | ASAIO Journal. 57:368-374 |
| ISSN: | 1058-2916 |
| DOI: | 10.1097/mat.0b013e318227f8a2 |
| Popis: | Despite successful resuscitation of donors after circulatory determination of death (DCD) with extracorporeal support (ECS), the technique is limited by ethical concerns about donor management (heparinization) and the complexity to operate the ECS circuit. This work studies different timing of heparin administration and the effects of ECS-perfusion temperature. Cardiac arrest (CA) was induced in swine. Heparin studies, three groups: 1) PRE5, heparin 5 minutes before CA; 2) POST5, heparin 5 minutes after CA, plus 2 minutes external chest compressions; and 3) POST30, heparin with the initiation of ECS after 30 minutes CA. Perfusion temperature study, two groups: 1) normothermic, ECS-38.5°C after 30 minutes CA and 2) room temperature, ECS-25.5°C for the first 90 minutes, followed by ECS-38.5°C. Heparin studies: ECS target flows (>50 ml/kg/min) were not achieved in the POST30 group, affecting local organ perfusion as observed with poor bile ( |
| Databáze: | OpenAIRE |
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