Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum
| Autor: | Guojian Zhang, Tianjiao Zhu, Dehai Li, Qianqun Gu, Jing-Yan Gu, Zhenjian Lin, Shiwei Sun |
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| Rok vydání: | 2011 |
| Předmět: |
Magnetic Resonance Spectroscopy
Chemical structure Plant Science Isoindoles Horticulture Antiviral Agents Biochemistry Cell Line Microbiology Dogs Influenza A Virus H1N1 Subtype Emericella Emericella sp Animals Molecular Biology Primulaceae Cytopathic effect Biological Products Molecular Structure biology Ascomycota General Medicine Myrsinaceae Endophytic fungus biology.organism_classification Fermentation Plant Bark Aegiceras corniculatum Sesquiterpenes |
| Zdroj: | Phytochemistry. 72:1436-1442 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/j.phytochem.2011.04.014 |
| Popis: | Chemical investigation of the endophytic fungus Emericella sp. (HK-ZJ) isolated from the mangrove plant Aegiceras corniculatum led to isolation of six isoindolones derivatives termed as emerimidine A and B and emeriphenolicins A and D, and six previously reported compounds named aspernidine A and B, austin, austinol, dehydroaustin, and acetoxydehydroaustin, respectively. Their structures were elucidated on the basis of NMR spectroscopic evidence while the anti-influenza A viral (H₁N₁) activities of eight compounds were also evaluated using the cytopathic effect (CPE) inhibition assay. |
| Databáze: | OpenAIRE |
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