A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit
| Autor: | Ben Morton, Zhenxing Cheng, Cheng Hock Toh, Simon T. Abrams, Mohmad Alsabani, Ingeborg Welters, Yasir Alhamdi, Steven Lane, Guozheng Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
wh_200
First line 030204 cardiovascular system & hematology Extracellular Traps law.invention 03 medical and health sciences 0302 clinical medicine law medicine Humans In patient Clinical significance 030212 general & internal medicine Interleukin 8 Disseminated intravascular coagulation business.industry Research General Medicine Neutrophil extracellular traps Disseminated Intravascular Coagulation medicine.disease Precision medicine Intensive care unit wb_102 Intensive Care Units wx_200 Immunology business |
| Zdroj: | Clinical medicine (London, England) Clin Med (Lond) |
| ISSN: | 1473-4893 1470-2118 |
| Popis: | Neutrophils are the first line of defence against bacterial infection, and formation of neutrophil extracellular traps (NETs) is an important protective mechanism. NETs can also be harmful by inducing intravascular coagulation and multi-organ failure (MOF) in animal models.1–6 Although increasingly considered as important therapeutic targets,7–9 there is currently no robust and specific measure of NET formation to inform clinical care and enable precision medicine in patients on the intensive care unit (ICU). The aim of this study is to establish a novel assay for measuring NETs and assess its clinical significance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|