Transplantation of GABAergic Interneuron Progenitor Attenuates Cognitive Deficits of Alzheimer's Disease Model Mice
| Autor: | Ruxiang Xu, Ting-Ting Pan, Ji-Bo Chen, Wen-Li Ji, De-En Xu, Yuchio Yanagawa, Qi-Fa Li, Quan-Hong Ma, Yue Zhang, Shao Li, Mei-Hong Lu, Xiu-Yun Zhao, Fen Wang, Ze-Ping Huang, Chun-Feng Liu, Lu-Lu Xue, Yi-Yuan Xia, Ting-Hua Wang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Interneuron Ganglionic eminence Mice Transgenic 03 medical and health sciences Amyloid beta-Protein Precursor Mice 0302 clinical medicine Cognition Neural Stem Cells Alzheimer Disease Interneurons mental disorders medicine Presenilin-1 Animals Cognitive Dysfunction Cognitive decline GABAergic Neurons Maze Learning Neuroinflammation biology General Neuroscience General Medicine Transplantation Psychiatry and Mental health Clinical Psychology Disease Models Animal 030104 developmental biology medicine.anatomical_structure nervous system Synaptic plasticity biology.protein GABAergic Geriatrics and Gerontology Neuroscience 030217 neurology & neurosurgery Parvalbumin |
| Zdroj: | Journal of Alzheimer's disease : JAD. 75(1) |
| ISSN: | 1875-8908 |
| Popis: | Excitatory (E) and inhibitory (I) balance of neural network activity is essential for normal brain function and of particular importance to memory. Disturbance of E/I balance contributes to various neurological disorders. The appearance of neural hyperexcitability in Alzheimer's disease (AD) is even suggested as one of predictors of accelerated cognitive decline. In this study, we found that GAD67+, Parvalbumin+, Calretinin+, and Neuropeptide Y+ interneurons were progressively lost in the brain of APP/PS1 mice. Transplanted embryonic medial ganglionic eminence derived interneuron progenitors (IPs) survived, migrated, and differentiated into GABAergic interneuron subtypes successfully at 2 months after transplantation. Transplantation of IPs hippocampally rescued impaired synaptic plasticity and cognitive deficits of APP/PS1 transgenic mice, concomitant with a suppression of neural hyperexcitability, whereas transplantation of IPs failed to attenuate amyloid-β accumulation, neuroinflammation, and synaptic loss of APP/PS1 transgenic mice. These observations indicate that transplantation of IPs improves learning and memory of APP/PS1 transgenic mice via suppressing neural hyperexcitability. This study highlights a causal contribution of GABAergic dysfunction to AD pathogenesis and the potentiality of IP transplantation in AD therapy. |
| Databáze: | OpenAIRE |
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