Myeloid dendritic cells in severe aplastic anemia patients exhibit stronger phagocytosis
| Autor: | Yingying Sun, Yang Zhang, Ningyuan Ran, Zonghong Shao, Chengcheng Wu, Chunyan Liu, Huaquan Wang, Yu Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Male Myeloid aplastic anemia Adolescent Phagocytosis Clinical Biochemistry cytotoxic T lymphocyte Young Adult White blood cell T helper medicine Immunology and Allergy Cytotoxic T cell Humans Aplastic anemia Child Research Articles Cells Cultured Aged Aged 80 and over business.industry Tumor Necrosis Factor-alpha Biochemistry (medical) mDC Public Health Environmental and Occupational Health Interleukin phagocytosis Anemia Aplastic Hematology Dendritic Cells Middle Aged medicine.disease Medical Laboratory Technology medicine.anatomical_structure Case-Control Studies Immunology Interleukin-2 Bone marrow business CD8 Research Article |
| Zdroj: | Journal of Clinical Laboratory Analysis |
| ISSN: | 1098-2825 0887-8013 |
| Popis: | Background A deeper understanding of the pathogenesis of severe aplastic anemia (SAA) is urgently warranted to achieve better therapeutic effects. The objective of this study was to investigate the phagocytosis of myeloid dendritic cell (mDC) in SAA patients. Methods Myeloid dendritic cells were induced in vitro from bone marrow mononuclear cells from 26 SAA patients and 12 normal controls (HCs). The phagocytosis of mDCs was detected by flow cytometry using FITC‐Dextran (40KD), and its correlation with the immune status and severity of the disease was analyzed. Results The phagocytosis of mDC from untreated SAA patients was significantly stronger than that from complete remission group and HC group (p 0.05). The phagocytosis of mDC from SAA patients correlated positively with the concentration of interleukin (IL)‐2 (r = 0.389, p Under the stimulation of antigenic or other factors, the phagocytosis of myeloid dendritic cells in newly diagnosed SAA patients was enhanced, which facilitates the polarization of Th0 to Th1, the activation of CTL, and finally the apoptosis of hematopoietic cells. |
| Databáze: | OpenAIRE |
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