Activity of hippocampal, amygdala, and neocortex during the Rey auditory verbal learning test: an event-related potential study in epileptic patients
| Autor: | Claudio, Babiloni, Fabrizio, Vecchio, Mirabella, Giovanni, Fabio, Sebastiano, Gennaro, Gd, Di Gennaro, G., Giancarlo Di Gennaro, Quarato, Pier P., Paola, Buffo, Vincenzo, Esposito, Mario, Manfredi, Cantore, Gianpaolo, Fabrizio, Eusebi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male p300 event-related potential immediate memory intracerebral electroencephalography (eeg) rey auditory verbal learning test Hippocampus Electroencephalography Neuropsychological Tests Amygdala Temporal lobe Event-related potential Physiology (medical) medicine Humans Evoked Potentials Analysis of Variance Brain Mapping Neocortex medicine.diagnostic_test Recall Brain Signal Processing Computer-Assisted Human brain Middle Aged Verbal Learning Sensory Systems Electrodes Implanted medicine.anatomical_structure Neurology Acoustic Stimulation Epilepsy Temporal Lobe Female Neurology (clinical) Psychology Neuroscience psychological phenomena and processes |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 121(8) |
| ISSN: | 1872-8952 |
| Popis: | Objective Previous evidence in epileptic subjects has shown that theta (about 4–7 Hz) and gamma rhythms (about 40–45 Hz) of hippocampus, amygdala, and neocortex were temporally synchronized during the listening of repeated words successfully remembered ( Babiloni et al., 2009 ). Here we re-analyzed those electroencephalographic (EEG) data to test whether a parallel increase in amplitude of late positive event-related potentials takes place. Methods Intracerebral electroencephalographic (EEG) activity had been recorded in five subjects with drug-resistant temporal lobe epilepsy, undergoing pre-surgical evaluation. During the recording of the intracerebral EEG activity, the subjects performed a computerized version of the Rey auditory verbal learning test (RAVLT). They heard the same list of 15 common words for five times. Each time, immediately after the listening of the list, the subjects were required to repeat as many words as they could recall. Results We found that late positive event-related potentials (ERPs) peaking at about 350 ms post-stimulus in amygdala, hippocampus, and occipital–temporal cortex had a higher amplitude during the listening of the repeated words that were subsequently recalled than for those that were not recalled. Conclusions Late positive ERPs reflect a functional mechanism implemented in a human brain network spanning amygdala, hippocampus, and occipital–temporal cortex which is at the basis of the memorization processes of verbal materials. Significance This ERP component is a promising neuromarker of successful memorization of repeated words in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect