Allicin stimulates lymphocytes and elicits an antitumor effect: a possible role of p21ras
| Autor: | Aharon Rabinkov, Alexey Vanichkin, Meir Wilchek, Harry M. Lander, Abraham Novogrodsky, Miriam Patya, Talia Miron, Muayad A. Zahalka, David Mirelman |
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| Rok vydání: | 2004 |
| Předmět: |
Cytotoxicity
Immunologic Lymphocyte T-Lymphocytes Immunology Pharmacology Biology Oncogene Protein p21(ras) Lymphocyte Activation Peripheral blood mononuclear cell Jurkat cells chemistry.chemical_compound Jurkat Cells Mice Anti-Infective Agents medicine Splenocyte Immunology and Allergy Animals Humans Disulfides Cytotoxicity Fibrosarcoma Allicin Kinase Macrophages General Medicine Neoplasms Experimental medicine.disease Sulfinic Acids Enzyme Activation Mice Inbred C57BL medicine.anatomical_structure chemistry Biochemistry Amino Acid Substitution Oxidation-Reduction Signal Transduction |
| Zdroj: | International immunology. 16(2) |
| ISSN: | 0953-8178 |
| Popis: | Allicin, the main organic allyl sulfur component in garlic, exhibits immune-stimulatory and antitumor properties. Allicin stimulated [(3)H]thymidine incorporation in mouse splenocytes and enhanced cell-mediated cytotoxicity in human peripheral mononuclear cells. Multiple administration (i.p.) of allicin elicited a marked antitumor effect in mice inoculated with B-16 melanoma and MCA-105 fibrosarcoma. The immune-stimulatory and antitumor effects of allicin are characterized by a bell-shaped curve, i.e. allicin at high, supra-optimal concentrations is less effective or inhibitory. Allicin induced activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in human peripheral mononuclear cells, and also in wild-type Jurkat T-cells. Allicin failed to activate ERK1/2 in Jurkat T cells that express p21(ras), in which Cys118 was replaced by Ser. These cells are not susceptible to redox-stress modification and activation. We postulate that the immune stimulatory effect of allicin is mediated by redox-sensitive signaling such as activation of p21(ras). It is suggested that the antitumor effect of allicin is related to its immune-stimulatory properties. |
| Databáze: | OpenAIRE |
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