Influence of low dose allopurinol on ischaemia — Reperfusion injury during abdominal aortic surgery
| Autor: | Howard M. Berger, J. Hajo van Bockel, H. J. Smeets, Job Kievit, Jan Camps, Jo Hermans, A.W. Marc van Milligen de Wit |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Swine
Allopurinol Serum albumin Thiobarbituric Acid Reactive Substances Antioxidants Capillary Permeability Placebos Random Allocation Blood vessel prosthesis Ischemia Thiobarbituric acid reactive species medicine TBARS Animals Single-Blind Method Aorta Abdominal Muscle Skeletal Microvascular permeability Creatine Kinase Serum Albumin Medicine(all) biology business.industry Albumin Technetium Shock Ascorbic acid medicine.disease Blood Vessel Prosthesis Shock (circulatory) Anesthesia Reperfusion Injury Ischaemia-reperfusion biology.protein Surgery Creatine kinase Female medicine.symptom Cardiology and Cardiovascular Medicine business Reperfusion injury Oxidation-Reduction Aortic surgery medicine.drug Granulocytes |
| Zdroj: | European Journal of Vascular and Endovascular Surgery. 9(2):162-169 |
| ISSN: | 1078-5884 |
| DOI: | 10.1016/s1078-5884(05)80085-1 |
| Popis: | Objectives: To ascertain whether surgery causes ischaemia-reperfusion (I-R) related injury, if this injury is augmented by preoperative shock, and reduced with low dose allopurinol. Design: Randomised blind placebo controlled trial. Setting: Surgical laboratory. Material and methods: 22 pigs were randomly allocated to four groups; OP=operation/placebo, OA=operation/allopurinol, SOP=shock + operation/placebo, SOA=shock + operation/allopurinol. An aortic tube prosthesis was inserted in all. In groups SOP and SOA preoperative shock was induced by exsanguination. Allopurinol was administered in group OA on the preoperative day and peroperatively, in group SOA during shock and peroperatively. Chief outcome measures: Perioperative blood concentrations of thiobarbituric acid reactive species (TBARS), ascorbic acid (AA), albumin, 99m Tc-albumin and creatine phosphokinase (CPK) as indicators of oxidative membrane damage, antioxidant activity, microvascular permeability changes and muscular cell damage respectively. Main results: In the OP and OA groups TBARS gradually increased, while AA, 99m Tc-albumin and CPK remained unchanged and albumin decreased. No effect of allopurinol was observed in these groups. In the SOP group TBARS and AA were not significantly different from groups OP and OA. Yet, albumin, 99m Tc-albumin and CPK decreased significantly more in the SOP group. Compared with the SOP group, allopurinol treatment (SOA) produced lower TBARS and higher AA levels, and reduced the effect of shock on albumin, 99m Tc-albumin and CPK concentrations. Conclusion: Aortic surgery causes no I-R related damage. Pre-operative shock produces I-R related damage, which is reduced by allopurinol. |
| Databáze: | OpenAIRE |
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