A 3-D model used to explore how cell adhesion and stiffness affect cell sorting and movement in multicellular systems
| Autor: | Eirikur Palsson |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Statistics and Probability
Cell type Cell Models Biological General Biochemistry Genetics and Molecular Biology Dictyostelium discoideum Extracellular matrix Imaging Three-Dimensional Cell Movement Cell Adhesion Cyclic AMP Morphogenesis medicine Animals Computer Simulation Dictyostelium Cell adhesion Cell Size Life Cycle Stages General Immunology and Microbiology biology Chemotaxis Applied Mathematics fungi General Medicine Adhesion Cell sorting biology.organism_classification Biomechanical Phenomena Cell biology medicine.anatomical_structure Modeling and Simulation Rheology General Agricultural and Biological Sciences |
| Zdroj: | Journal of Theoretical Biology. 254:1-13 |
| ISSN: | 0022-5193 |
| DOI: | 10.1016/j.jtbi.2008.05.004 |
| Popis: | A three-dimensional mathematical model is used to determine the effects of adhesion and cell signalling on cell movements during the aggregation and slug stages of Dictyostelium discoideum (Dd) and to visualize cell sorting. The building blocks of the model are individual deformable ellipsoidal cells, where movement depends on internal parameter state (cell size and stiffness) and on external cues from the neighboring cells, extracellular matrix, and chemical signals. Cell movement and deformation are calculated from equations of motion using the total force acting on each cell, ensuring that forces are balanced. The simulations show that the sorting patterns of prestalk and prespore cells, emerging during the slug stage, depend critically on the type of cell adhesion and not just on chemotactic differences between cells. This occurs because cell size and stiffness can prevent the otherwise faster cells from passing the slower cells. The patterns are distinctively different when the prestalk cells are more or less adhesive than the prespore cells. These simulations suggest that sorting is not solely due to differential chemotaxis, and that differences in both adhesion strength and type between different cell types play a very significant role, both in Dictyostelium and other systems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect