Importance of the Keratinized Epithelial Cell in Bacterial Adherence
| Autor: | Debra Jan Bibel, Howard I. Maibach, Henry R. Shinefield, Walter G. Strauss, Raza Aly |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Cellular pathology
Staphylococcus aureus Mucous membrane of nose Dermatology Biology medicine.disease_cause Bacterial Physiological Phenomena Biochemistry Epithelium Microbiology Dermatitis Atopic chemistry.chemical_compound Psoriasis Skin Physiological Phenomena Keratin medicine Humans Molecular Biology Skin chemistry.chemical_classification Teichoic acid integumentary system Adhesiveness Cell Biology Atopic dermatitis medicine.disease Nasal Mucosa medicine.anatomical_structure chemistry Keratins |
| Zdroj: | Journal of Investigative Dermatology. (4):250-253 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12500072 |
| Popis: | The effect of cellular pathology and keratinization of skin and nasal cells upon binding of Staphylococcus aureus were examined. Adherence with epithelial cells obtained from either the skin or nasal mucosa of patients with atopic dermatitis was greater than that observed with normal cells (p less than 0.001); the difference in adherence between psoriatic and normal cells was not statistically significant. Tested nasal cells were microscopically differentiated into 4 general types based on stage or layer of keratinization: spinous, low granular, high granular, and keratin. The degree of adherence was related to the progress of keratinization. Data indicated the existence of 2 types of receptors for S. aureus on nasal cells: One, present upon both granular and fully keratinized cells, is not blocked by teichoic acid and appears responsible for the higher bacterial counts on atopic cells; the second is found on keratinized cells only and is susceptible to teichoic acid. |
| Databáze: | OpenAIRE |
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