Tricyclic imipramine modification of the circadian rhythms of hypothalamic serotonin, its precursors and acid catabolite in individually housed rats
| Autor: | P. De Franciscis, Gambardella P, Diego D'Aponte, Anna Maria Greco, Sticchi R |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Imipramine Serotonin Physiology Hypothalamus Biology 5-Hydroxytryptophan chemistry.chemical_compound Reference Values Physiology (medical) Internal medicine medicine Animals Circadian rhythm Neurotransmitter 5-HT receptor Chronobiology 5-Hydroxyindoleacetic acid Tryptophan Rats Inbred Strains Hydroxyindoleacetic Acid Circadian Rhythm Rats Endocrinology chemistry medicine.drug |
| Zdroj: | Chronobiology international. 5(3) |
| ISSN: | 0742-0528 |
| Popis: | Circadian rhythms of serotonin (5HT), its precursors tryptophan (TP) and 5-hydroxy-tryptophan (5HTP) and its acid catabolite 5-hydroxy-indoleacetic acid (5HIAA), were determined in the hypothalamus of control rats and rats which had been treated continuously with subcutaneous imipramine (10 mg/kg/day) for 2 weeks. Rats were individually housed and entrained to LD 12:12. Controls showed the 5HT and TP peaks in the light and dark periods respectively, as reported in the literature, but no inverted correlation (antiphase) between 5HT and 5HIAA rhythms. Imipramine significantly modified circadian rhythm characteristics: the 5HT acrophase was advanced, that of TP and 5HIAA was delayed. Imipramine also significantly increased hypothalamic 5HT and TP concentrations. |
| Databáze: | OpenAIRE |
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