CT-Determined Sarcopenia in GLIM-Defined Malnutrition and Prediction of 6-Month Mortality in Cancer Inpatients
Autor: | Jose Abuín-Fernández, Francisco José Sánchez-Torralvo, Gabriel Olveira, Inmaculada González-Almendros, Ignacio Ruiz-García, Manuel Barrios, Emilio Alba, Victoria Contreras-Bolívar, María Ruiz-Vico |
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Přispěvatelé: | [Sánchez-Torralvo,FJ, Ruiz-García,I, Abuín-Fernández,J, Olveira,G] Unidad de Gestión Clínica de Endocrinología y Nutrición, IBIMA, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain. [Contreras-Bolívar,V] UGG Endocrinology and Nutrition at the University Hospital San Cecilio, Granada, Spain. [González-Almendros,I] Unidad de Gestión Clínica de Radiodiagnóstico, Hospital Regional Universitario de Málaga, Málaga, Spain. [Ruiz-Vico,M, Alba,E] Unidad de Gestión Clínica de Oncología Médica, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain. [Barrios,M] Unidad de Gestión Clínica de Hematología y Hemoterapia, Hospital Regional Universitario de Málaga, Málaga, Spain., This research was partially funded by an unlimited grant from Abbott Laboratories SA (Spain). Ignacio Ruiz-García is the recipient of a Río Hortega grant CM20/00225 from the Instituto de Salud Carlos III and co-funded by Fondo Social Europeo 2014–2020. This research was funded by the Junta de Andalucía (PI-0268-2019). V.C.-B. is funded by postdoctoral fellowships from the Junta de Andalucía (RH-0141-2020). |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Male Desnutrición Sarcopenia Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] 0302 clinical medicine Estado nutricional Neoplasms TX341-641 Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional Status [Medical Subject Headings] Prospective Studies Prospective cohort study Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings] Nutrition and Dietetics GLIM criteria Anatomy::Musculoskeletal System::Muscles::Muscle Skeletal [Medical Subject Headings] Diseases::Neoplasms [Medical Subject Headings] Middle Aged Oncología médica medicine.anatomical_structure 030220 oncology & carcinogenesis oncology Female Tomografía computarizada por rayos X Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Malnutrition [Medical Subject Headings] medicine.medical_specialty Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings] education Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Tomography X-Ray::Tomography X-Ray Computed [Medical Subject Headings] Check Tags::Male [Medical Subject Headings] GLIM Nutritional Status Muscle mass Article 03 medical and health sciences Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Nutrition Assessment [Medical Subject Headings] Internal medicine medicine Humans Muscle Skeletal Composición corporal Aged Inpatients body composition 030109 nutrition & dietetics Nutrition. Foods and food supply Psychiatry and Psychology::Behavior and Behavior Mechanisms::Personality::Leadership [Medical Subject Headings] business.industry Malnutrition Persons::Persons::Patients::Inpatients [Medical Subject Headings] Cancer Skeletal muscle Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Body Composition [Medical Subject Headings] Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] computed tomography medicine.disease Confidence interval Diseases::Nervous System Diseases::Neurologic Manifestations::Neuromuscular Manifestations::Muscular Atrophy::Sarcopenia [Medical Subject Headings] Leadership Nutrition Assessment Check Tags::Female [Medical Subject Headings] business Tomography X-Ray Computed Food Science |
Zdroj: | Nutrients Volume 13 Issue 8 Nutrients, Vol 13, Iss 2647, p 2647 (2021) |
ISSN: | 2072-6643 |
Popis: | Our objective was to evaluate the clinical application of third lumbar vertebra (L3)-computer tomography (CT)-determined sarcopenia as a marker of muscle mass in cancer inpatients diagnosed with malnutrition according to the Global Leadership Initiative on Malnutrition (GLIM) criteria and to establish its association with 6-month mortality. Methods: This was an observational, prospective study in patients from an inpatient oncology unit. We performed a nutritional assessment according to GLIM criteria, including muscle cross-sectional area at L3 by CT and skeletal muscle index (SMI). Six-month mortality was evaluated. Results: A total of 208 patients were included. The skeletal muscle cross-sectional area at L3 was 136.2 ± 32.5 cm2 in men and 98.1 ± 21.2 cm2 in women. The SMI was 47.4 ± 12.3 cm2/m2 in men and 38.7 ± 8.3 cm2/m2 in women. Sarcopenia (low SMI) was detected in 59.6% of the subjects. Using SMI as a marker of low muscle mass in application of GLIM criteria, we found 183 (87.9%) malnourished patients. There were 104 deaths (50%) at 6 months. The deceased patients had a lower skeletal muscle cross-sectional area (112.9 ± 27.9 vs. 126.1 ± 37.8 cm2 p = 0.003) and a lower SMI (41.3 ± 9.5 vs. 45.7 ± 12.9 cm2/m2 p = 0.006). An increased risk of 6-month mortality was found in malnourished patients according to GLIM criteria using SMI (HR 2.47 95% confidence interval 1.07–5.68 p = 0.033). Conclusions: Low muscle mass, assessed by L3-CT, was observed to affect more than half of cancer inpatients. The deceased patients at 6 months had a lower skeletal muscle cross-sectional area and SMI. Malnutrition according to GLIM criteria using CT-determined sarcopenia was shown to adequately predict 6-month mortality. |
Databáze: | OpenAIRE |
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