Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study
| Autor: | J.D. van Klaveren, A.J.M. van Loon, R.A. Goldbohm, Anita Botterweck, H.A.M. Brants, P.A. van den Brandt |
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| Přispěvatelé: | Epidemiologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, Centraal Instituut voor Voedingsonderzoek TNO |
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Male
Cancer Research Nitrite Rate ratio Nitrate Gastroenterology Cohort Studies chemistry.chemical_compound Cancer risk Food intake Smoking habit Prospective Studies Prospective cohort study Stomach cancer Netherlands Beta carotene Middle Aged Oncology Ascorbic acid Female Cohort analysis Cohort study Research Article Adult Risk medicine.medical_specialty Dietary Data analysis Drinking Major clinical study Stomach Neoplasms Internal medicine medicine Drinking water Humans Risk factor Nitrites Nutrition Aged Nitrates business.industry Questionnaire Dietary intake Cancer medicine.disease Endocrinology chemistry Food Carcinogens business Gastric cancer Cancer incidence |
| Zdroj: | British Journal of Cancer, 78(1), 1129-135. Nature Publishing Group British Journal of Cancer, 1, 78, 129-135 British Journal of Cancer |
| ISSN: | 0007-0920 |
| DOI: | 10.1038/bjc.1998.454 |
| Popis: | University Masstricht, Department of Epidemiology, The Netherlands.The association between the intake of nitrate or nitrite and gastric cancer risk was investigated in a prospective cohort study started in 1986 in the Netherlands, of 120,852 men and women aged 55-69 years. At baseline, data on dietary intake, smoking habits and other covariates were collected by means of a self-administered questionnaire. For data analysis, a case-cohort approach was used, in which the person-years at risk were estimated from a randomly selected subcohort (1688 men and 1812 women). After 6.3 years of follow-up, 282 microscopically confirmed incident cases of stomach cancer were detected: 219 men and 63 women. We did not find a higher risk of gastric cancer among people with a higher nitrate intake from food [rate ratio (RR) highest/lowest quintile = 0.80, 95% CI 0.47-1.37, trend-P = 0.18], a higher nitrate intake from drinking water (RR highest/lowest quintile = 0.88, 95% CI 0.59-1.32, trend-P = 0.39) or a higher intake of nitrite (RR highest/lowest quintile = 1.44, 95% CI 0.95-2.18, trend-P = 0.24). Rate ratios for gastric cancer were also computed for each tertile of nitrate intake from foods within tertiles of vitamin C intake and intake of beta-carotene, but no consistent pattern was found. Therefore, our study does not support a positive association between the intake of nitrate or nitrite and gastric cancer risk. |
| Databáze: | OpenAIRE |
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