Longitudinal Results of Intratympanic Injection of Budesonide for Otitis Media With Effusion in Children Over 12 Years and Adults
| Autor: | Fengling Yang, Hong Zheng, Ping An, Yu Zhao, Yongbo Zheng, Rong Yu, Deying Gu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Budesonide Pediatrics medicine.medical_specialty Adolescent Anti-Inflammatory Agents Ear Middle Kaplan-Meier Estimate Audiology Dexamethasone Injections law.invention Young Adult Randomized controlled trial law medicine Humans Single-Blind Method Longitudinal Studies Young adult Child Curative effect Otitis Media with Effusion business.industry Follow up studies Middle Aged Survival Analysis Sensory Systems Treatment Outcome Otitis Otorhinolaryngology Effusion Female Neurology (clinical) medicine.symptom business Follow-Up Studies medicine.drug |
| Zdroj: | Otology & Neurotology. 35:629-634 |
| ISSN: | 1531-7129 |
| DOI: | 10.1097/mao.0000000000000212 |
| Popis: | To assess the longitudinal curative effect and improvement of subjective symptoms by using intratympanic injection of Budesonide(BUD) for otitis media with effusion (OME) patients older than 12 years and adults.A single-blind, randomized, parallel-controlled prospective study.Hospital, outpatient.Ninety patients (112 ears) who were diagnosed as having OME were recruited and then randomized to BUD, dexamethasone (DEX), and sodium chloride (NS) groups, the latter two served as controls.The randomly allocated patients received intratympanic injection of BUD (0.5 mg/1 ml), DEX (2 mg/1 ml), or 0.9% NS solution (1 ml) once a week.Survival analysis was applied to compare the longitudinal curative effects among the 3 groups. Meanwhile, the 6 main subjective symptoms were scored by 10-point visual scale, and physician's evaluations were preformed during treatment and follow-up.After adjustment for course of disease, volume, and characters of effusion, the relative risk (RR) of BUD is 0.139 (95% CI, 0.054-0.358) when compared with NS. Survival curve demonstrated that the rank of longitudinal therapeutic efficacy was BUD, DEX, and NS (p0.05). Both BUD and DEX showed improvements in subjective symptoms and quality of life compared with NS (p0.05). In the aspect of improving the symptom of stuffy ear, BUD showed advantage over both DEX and NS. During and after treatment, no serious complications or sequelae were observed.Intratympanic injection with BUD for OME patients showed advantages in improving long-term therapeutic efficacy, it was a safe and effective intervention for adolescents and adults with OME. |
| Databáze: | OpenAIRE |
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