Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome
| Autor: | Shutong Yao, Shucun Qin, Xiuhong Li, Chuanlong Zong, Yazhuo Xue, Guohua Song, Min Li, Yang Yu, Liying Zhang, Hui Sang |
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| Rok vydání: | 2013 |
| Předmět: |
Apolipoprotein E
Adult Male medicine.medical_specialty Apolipoprotein B QD415-436 medicine.disease_cause Biochemistry Antioxidants Superoxide dismutase chemistry.chemical_compound Endocrinology High-density lipoprotein Internal medicine medicine apolipoprotein B Humans antioxidative property Research Articles Apolipoproteins B Metabolic Syndrome biology Cholesterol Cholesterol HDL Water Cell Biology Cholesterol LDL Middle Aged medicine.disease Oxidative Stress chemistry high density lipoprotein Low-density lipoprotein biology.protein lipids (amino acids peptides and proteins) Female Metabolic syndrome low density lipoprotein Oxidative stress Hydrogen |
| Zdroj: | Journal of Lipid Research, Vol 54, Iss 7, Pp 1884-1893 (2013) |
| ISSN: | 1539-7262 |
| Popis: | We have found that hydrogen (dihydrogen; H2) has beneficial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters. The objective of this study was to characterize the effects of H2-rich water (0.9–1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syndrome. Serum analysis showed that consumption of H2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels. Western blot analysis revealed a marked decrease of apolipoprotein (apo)B100 and apoE in serum. In addition, we found H2 significantly improved HDL functionality assessed in four independent ways, namely, i) protection against LDL oxidation, ii) inhibition of tumor necrosis factor (TNF)-α-induced monocyte adhesion to endothelial cells, iii) stimulation of cholesterol efflux from macrophage foam cells, and iv) protection of endothelial cells from TNF-α-induced apoptosis. Further, we found consumption of H2-rich water resulted in an increase in antioxidant enzyme superoxide dismutase and a decrease in thiobarbituric acid-reactive substances in whole serum and LDL. In conclusion, supplementation with H2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome. |
| Databáze: | OpenAIRE |
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