Alcohol Consumption and Tryptophan Metabolism Among People with HIV Prior to Antiretroviral Therapy Initiation: The Uganda ARCH Cohort Study
| Autor: | Debbie M. Cheng, Judith A. Hahn, Peter W. Hunt, Christine Ngabirano, Jeffrey H. Samet, Yong Huang, Frantz Pierre, Kaku So-Armah, Winnie Muyindike, Michael Winter, Leah S Forman, Nneka Emenyonu |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Kynurenine pathway Alcohol Drinking HIV Infections Context (language use) Alcohol Article Oral and gastrointestinal Cohort Studies Substance Misuse Alcohol Use and Health 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Clinical Research Internal medicine medicine Humans Psychology Uganda 030212 general & internal medicine business.industry Tryptophan Neurosciences Substance Abuse General Medicine medicine.disease Stroke Alcoholism Infectious Diseases Mental Health Good Health and Well Being chemistry Cohort Public Health and Health Services HIV/AIDS Digestive Diseases Infection business Viral load 030217 neurology & neurosurgery Kynurenine Cohort study |
| Zdroj: | Alcohol and alcoholism (Oxford, Oxfordshire), vol 57, iss 2 Alcohol Alcohol |
| ISSN: | 1464-3502 0735-0414 |
| Popis: | Aims Alcohol is hypothesized to have effects on the kynurenine pathway of tryptophan catabolism, a potential mechanism for alcohol-induced depression and aggression. A biomarker of this pathway, the plasma kynurenine to tryptophan ratio (K/T ratio), has been associated with HIV progression, mortality and depression. Our aim was to assess whether hazardous alcohol consumption is associated higher K/T ratio among people with HIV. Methods Participants were a subset of the Uganda Alcohol Research Collaboration on HIV/AIDS Cohort. Alcohol consumption was categorized (abstinent, moderate and hazardous alcohol use) using the Alcohol Use Disorders Identification Test—Consumption and phosphatidylethanol (PEth). K/T ratio was the primary outcome. We used linear regression adjusted for age, sex, FIB-4, hepatitis B surface antigen, log (HIV viral load) to estimate the association between alcohol consumption and K/T ratio. Results Compared to abstinent participants, hazardous drinkers and moderate drinkers had higher K/T ratio but these differences did not reach statistical significance. Conclusions Our results suggest that hazardous alcohol consumption, in the context of untreated HIV infection, may not significantly alter kynurenine to tryptophan ratio as a measure of activity of the kynurenine pathway of tryptophan metabolism. |
| Databáze: | OpenAIRE |
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