Pathogenicity of Cilia-associated Respiratory (CAR) Bacillus Isolates for F344, LEW, and SD Rats
| Autor: | Trenton R. Schoeb, Jerry K. Davis, Maureen K. Davidson |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
0301 basic medicine
CAR bacillus 040301 veterinary sciences Respiratory System Bacillus Bacillaceae Infections Biology medicine.disease_cause Polymerase Chain Reaction Microbiology Rats Sprague-Dawley Rodent Diseases 0403 veterinary science 03 medical and health sciences medicine Animals Cilia Respiratory system Respiratory Tract Infections Bacillus (shape) General Veterinary Respiratory tract infections Cilium Rats Inbred Strains 04 agricultural and veterinary sciences Mycoplasma Pathogenicity biology.organism_classification Virology Rats Inbred F344 Rats RNA Bacterial 030104 developmental biology Rats Inbred Lew |
| Zdroj: | Veterinary Pathology. 34:263-270 |
| ISSN: | 1544-2217 0300-9858 |
| Popis: | We conducted experiments to test whether rats of F344, LEW, and SD strains differ in susceptibility to mycoplasma-free isolates of cilia-associated respiratory (CAR) bacillus, whether Mycoplasma pulmonis can affect expression of CAR bacillus disease, and whether isolates of CAR bacillus differ in virulence for rats. In the first experiment, 24 rats of each strain were inoculated intranasally with 107bacilli of CAR bacillus X1428D/AS, and 24 rats of each strain were inoculated with sterile medium (controls). Eight weeks later, eight inoculated rats and eight control rats of each strain were euthanatized, eight inoculated and eight control rats were given 106.5colony-forming units of M. pulmonis X1428D, and eight inoculated rats and eight control rats were sham inoculated. Four rats of each group were euthanatized 4 or 8 weeks after the second inoculation. Severity of lesions in nasal passages, middle ear, trachea, and lungs was assessed by scoring. Rats of all three strains given CAR bacillus had typical lesions of similar severity; M. pulmonis X1428D was avirulent and did not exacerbate CAR bacillus disease. In the second experiment, groups of eight rats of F344 and SD strains were given 105or 107CAR bacillus X1328E, X1428D/AS, or X2450D and euthanatized 8 or 16 weeks later. Isolates X1428D/AS and X2450D caused similar lesions in rats of both strains and at both doses, but CAR bacillus X1328E was avirulent. Rats of the tested strains are similarly susceptible to CAR bacillus disease, but CAR bacillus isolates differ in virulence. |
| Databáze: | OpenAIRE |
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