CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging
| Autor: | Ana L. Kolicheski, Ryan J. Uitti, Owen A. Ross, Michelle R Graff-Radford, Michael G. Heckman, Neill R. Graff-Radford, Francine Parfitt, Zbigniew K. Wszolek, Alexandra I. Soto-Beasley, Ronald L. Walton |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Apolipoprotein E THE JOURNAL OF GERONTOLOGY: Biological Sciences Aging Genotyping Techniques Apolipoprotein E2 media_common.quotation_subject Disease Bioinformatics Polymorphism Single Nucleotide White People Healthy Aging Humans Medicine Dementia Lectins C-Type Allele Alleles Aged media_common Aged 80 and over Successful aging business.industry Longevity Middle Aged medicine.disease Etiology Female Geriatrics and Gerontology business SNP array |
| Zdroj: | J Gerontol A Biol Sci Med Sci |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glz213 |
| Popis: | A number of efforts are underway to better understand the role of genetic variation in successful aging and longevity. However, to date, only two genes have been consistently associated with longevity in humans: APOE and FOXO3, with the APOE ɛ2 allele also protective against dementia. Recently, using an exome-wide SNP array approach, a missense variant CLEC3B c.316G>A (rs13963 p.S106G) was reported to associate with longevity in two independent cohorts of Japanese and Chinese participants. Interestingly, CLEC3B p.S106G is more frequent in Caucasian populations. Herein, we examined the frequency of CLEC3B p.S106G in a Caucasian series of 1,483 neurologically healthy individuals with a specific subset >80 years of age. Although our findings do not support an association between CLEC3B p.S106G and aging without neurological disease (p = .89), we confirmed the association between the APOE ε2 allele and better survival without neurological disease (p = .001). Further assessment of healthy aged cohorts that retain intact neurological function will be critical to understand the etiology of neurodegenerative disease and the role of age at risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|