Plasma levels of free fatty acid differ in patients with left ventricular preserved, mid-range, and reduced ejection fraction

Autor: Xuyong Zhao, Hao Chen, Jiang Wenbing, Wu Youyang, Zhu Ning, Yi Wang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Blood Pressure
Pilot Projects
030209 endocrinology & metabolism
Heart failure
Fatty Acids
Nonesterified
030204 cardiovascular system & hematology
Positive correlation
Ventricular Function
Left
03 medical and health sciences
Reduced ejection fraction
0302 clinical medicine
Internal medicine
medicine
Humans
In patient
Aged
Angiology
Aged
80 and over
chemistry.chemical_classification
Ejection fraction
Free fatty acid
business.industry
Fatty acid
Stroke Volume
Plasma levels
Preserved ejection fraction
medicine.disease
Up-Regulation
Cardiac surgery
chemistry
lcsh:RC666-701
Hypertension
Cardiology
Female
Energy Metabolism
Cardiology and Cardiovascular Medicine
business
Mid-range ejection fraction
Biomarkers
Research Article
Zdroj: BMC Cardiovascular Disorders, Vol 18, Iss 1, Pp 1-8 (2018)
BMC Cardiovascular Disorders
ISSN: 1471-2261
DOI: 10.1186/s12872-018-0850-0
Popis: Background Free fatty acids (FFAs) predicted the risk of heart failure (HF) and were elevated in HF with very low left ventricular ejection fraction (LVEF) compared to healthy subjects. The aim of this study was to investigate whether total levels of FFA in plasma differed in patients with HF with preserved (HFpEF), mid-range (HFmrEF), and reduced ejection fraction (HFrEF) and the association with the three categories. Methods One hundred thirty-nine patients with HFpEF, HFmrEF and HFrEF were investigated in this study. Plasma FFA levels were measured using commercially available assay kits, and LVEF was calculated by echocardiography with the Simpson biplane method. Dyspnea ranked by New York Heart Association (NYHA) was also identified. Results FFA concentrations were higher in HFrEF than in HFmrEF and HFpEF, respectively (689 ± 321.5 μmol/L vs. 537.9 ± 221.6 μmol/L, p = 0.036; 689 ± 321.5 μmol/L vs. 527.5 ± 185.5 μmol/L, p = 0.008). No significant differences in FFA levels were found between HFmrEF and HFpEF (537.9 ± 221.6 μmol/L vs. 527.5 ± 185.5 μmol/L, p = 0.619). In addition, we found a negative correlation between FFA levels and LVEF (regression coefficient: − 0.229, p = 0.004) and a positive correlation between FFAs and NYHA class (regression coefficient: 0.214, p = 0.014) after adjustment for clinical characteristic, medical history and therapies. ROC analysis revealed that FFAs predicted HFrEF across the three categories (AUC: 0.644, p = 0.005) and the optimal cut-off level to predict HFrEF was FFA levels above 575 μmol/L. Conclusions FFA levels differed across the three categories, which suggests that energy metabolism differs between HFpEF, HFmrEF and HFrEF.
Databáze: OpenAIRE
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