COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside
Autor: | Yaqian Xu, Ashley S. Harms, Anna S. Nordvig, Luigi Zecca, James E. Goldman, K. Ray Chaudhuri, Elena Moro, Valentina Leta, Alessandro Sette, Stanley Fahn, Osama Al-Dalahmah, Richard J. Smeyne, David Sulzer, Olimpia Meucci, Angelo Antonini, Luigi Bubacco |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Parkinson's disease Encephalopathy Central nervous system Neuropathology Disease Virus lcsh:RC346-429 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Hyposmia Medicine lcsh:Neurology. Diseases of the nervous system business.industry Parkinsonism Translational research medicine.disease 030104 developmental biology medicine.anatomical_structure Neurology Perspective Immunology Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
Zdroj: | npj Parkinson's Disease, Vol 6, Iss 1, Pp 1-10 (2020) NPJ Parkinson's Disease |
ISSN: | 2373-8057 |
Popis: | This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson’s disease. Major points include that neuropathology studies have not answered the central issue of whether the virus enters central nervous system neurons, astrocytes or microglia, and the brain vascular cell types that express virus have not yet been identified. Currently, there is no clear evidence for human neuronal or astrocyte expression of angiotensin-converting enzyme 2 (ACE2), the major receptor for viral entry, but ACE2 expression may be activated by inflammation, and a comparison of healthy and infected brains is important. In contrast to the 1918 influenza pandemic and avian flu, reports of encephalopathy in COVID-19 have been slow to emerge, and there are so far no documented reports of parkinsonism apart from a single case report. We recommend consensus guidelines for the clinical treatment of Parkinson’s patients with COVID-19. While a role for the virus in causing or exacerbating Parkinson’s disease appears unlikely at this time, aggravation of specific motor and non-motor symptoms has been reported, and it will be important to monitor subjects after recovery, particularly for those with persisting hyposmia. |
Databáze: | OpenAIRE |
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