Analysis of patchclamp recordings: model-free multiscale methods and software

Autor: Benjamin Eltzner, Axel Munk, Florian Pein
Přispěvatelé: Pein, Florian [0000-0002-7994-9264], Apollo - University of Cambridge Repository
Rok vydání: 2020
Předmět:
Zdroj: European Biophysics Journal
ISSN: 1432-1017
Popis: Analysis of patchclamp recordings is often a challenging issue. We give practical guidance how such recordings can be analyzed using the model-free multiscale idealization methodology JSMURF, JULES, and HILDE. We provide an operational manual how to use the accompanying software available as an R-package and as a graphical user interface. This includes selection of the right approach and tuning of parameters. We also discuss advantages and disadvantages of model-free approaches in comparison to hidden Markov model approaches and explain how they complement each other. Supplementary Information The online version contains supplementary material available at 10.1007/s00249-021-01506-8.
Databáze: OpenAIRE
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