Aflatoxin exposure in pregnant women of mixed status of human immunodeficiency virus infection and rate of gestational weight gain: a Ugandan cohort study
| Autor: | Jacqueline M. Lauer, Jeffrey K. Griffiths, Shibani Ghosh, Jia-Sheng Wang, Barnabas K. Natamba, Patrick Webb |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Aflatoxin Adolescent pregnancy outcomes résultats de la grossesse 030231 tropical medicine Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Aflatoxins aflatoxine Pregnancy Interquartile range Antiretroviral Therapy Highly Active medicine Humans Maternal Health Services Uganda Pregnancy Complications Infectious business.industry Obstetrics Public Health Environmental and Occupational Health aflatoxin HIV VIH Prenatal Care medicine.disease Gestational Weight Gain Infectious Diseases Tropical medicine Gestation Female Original Article Parasitology medicine.symptom Ouganda business Original Research Papers Weight gain Cohort study |
| Zdroj: | Tropical Medicine & International Health |
| ISSN: | 1365-3156 1360-2276 |
| DOI: | 10.1111/tmi.13457 |
| Popis: | To examine the association between aflatoxin (AF) exposure during pregnancy and rate of gestational weight gain (GWG) in a sample of pregnant women of mixed HIV status in Gulu, northern Uganda.403 pregnant women were included (133 HIV-infected on antiretroviral therapy (ART), 270 HIV-uninfected). Women's weight, height and socio-demographic characteristics were collected at baseline (~19 weeks' gestation); weight was assessed at each follow-up visit. Serum was collected at baseline and tested for aflatoxin BAFB-lys levels (detected in 98.3% of samples) were higher among HIV-infected pregnant women than HIV-uninfected pregnant women [median (interquartile range): 4.8 (2.0, 15.0) vs. 3.5 (1.6, 6.1) pg/mg of albumin, P 0.0001]. Adjusting for HIV status, a one-log increase in aflatoxin levels was associated with a 16.2 g per week lower rate of GWG (P = 0.028). The association between AFB-lys and the rate of GWG was stronger and significant only among HIV-infected women on ART [-25.7 g per week per log (AFB-lys), P = 0.009 for HIV-infected women vs. -7.5 g per week per log (AFB-lys), P = 0.422 for HIV-uninfected women].Pregnant women with higher levels of AF exposure had lower rates of GWG. The association was stronger for HIV-infected women on ART, suggesting increased risk.Examiner l'association entre l'exposition à l'aflatoxine (AF) pendant la grossesse et le taux de gain de poids pendant la grossesse (GWG) dans un échantillon de femmes enceintes de statut mixte VIH à Gulu, dans le nord de l' Ouganda. MÉTHODES: 403 femmes enceintes ont été incluses (133 infectées par le VIH sous traitement antirétroviral (ART), 270 non infectées par le VIH). Le poids, la taille et les caractéristiques sociodémographiques des femmes ont été collectés au départ (~19 semaines de gestation); le poids a été évalué à chaque visite de suivi. Le sérum a été recueilli au départ et testé pour les niveaux d'adduit d'aflatoxine BLes femmes enceintes présentant des niveaux plus élevés d'exposition à l’AF avaient des taux de GWG plus faibles. L'association était plus forte pour les femmes infectées par le VIH sous ART, ce qui suggère un risque accru. |
| Databáze: | OpenAIRE |
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