The sheep genome illuminates biology of the rumen and lipid metabolism

Autor: Stephen M. J. Searle, Guodong Huang, Graham R. Cam, Xinhua Yang, Yaojing Yue, Moira Menzies, Thibaut Hourlier, Chen Ye, John C. McEwan, Sean McWilliam, Sandra L. Lee, Shalini N. Jhangiani, Donna M. Muzny, Stephen N. White, David Robelin, Peng Zeng, Michael Holder, Wenguang Zhang, Margaret A. Highland, Shengkai Pan, Shaoyin Fu, Bertrand Servin, Christie Kovar, Wenliang Wang, Yang Dong, Richard Talbot, Thomas Faraut, Paul Flicek, Min Xie, Chao Bian, Xun Xu, V. Hutton Oddy, I.R. Franklin, David L. Adelson, Chunhua Wu, Changxin Lu, James Kijas, Udaya DeSilva, Yuxiang Li, Bronwen Aken, Pablo Fuentes-Utrilla, Yulin Chen, Bin Wei, Richard A. Gibbs, Wen Wang, Aaron Ingham, Rui Guan, Weiqing Liu, Qing Zhou, Divya Kalra, Tittu Mathew, Jo-Ann L. Stanton, Shifeng Cheng, Huw E. Jones, Wenbin Chen, Jacob B. Hansen, W. Barris, Kim C. Worley, Karen Dixen, Noelle E. Cockett, Alan Archibald, Christopher C. Warkup, Jun Wang, Rudiger Brauning, Guangyi Fan, Yu Jiang, Tian Lv, Jillian F. Maddox, David Townley, Brian P. Dalrymple, Frank W. Nicholas, Karsten Kristiansen, Xin Liu
Přispěvatelé: Animal, Food and Health Sciences, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Northwest A&F University, Kunming Institute of Zoology, State Key Laboratory of Genetic Resources and Evolution, Chinese Academy of Sciences [Changchun Branch] (CAS), Beijing Genomics Institute [Shenzhen] (BGI), University of Edinburgh, Utah State University (USU), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Human Genome Sequencing Center, Baylor College of Medicine (BCM), Baylor University-Baylor University, Inner Mongolia Agricultural University (IMAU), Nei Mongol Bio-Information, Partenaires INRAE, Department of Anatomy, University of Otago [Dunedin, Nouvelle-Zélande], Invermay Agricultural Centre, AgResearch Ltd, The Wellcome Trust Sanger Institute [Cambridge], European Molecular Biology Laboratory, European Bioinformatics Institute, Department of Biology, Northern Arizona University [Flagstaff], Kunming Institute of Zoology, Chinese Academy of Sciences [Beijing] (CAS), Department of Veterinary Microbiology and Pathology, Washington State University (WSU), United States Department of Agriculture (USDA), Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Sichuan Agricultural University, Lanzhou Institute of Husbandry and Pharmaceutical Science, BBSRC Roslin Institute, School of Environmental and Rural Science, University of New England (UNE), Faculty of Veterinary Science, The University of Sydney, Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Macau University of Science and Technology (MUST), The Roslin Institute and Royal (Dick) School of Veterinary Studies, one 973 Program [2013CB835200], one CAS Program [XDB13000000], BGI-Shenzhen [ZYC200903240077A, ZYC200903240078A], Inner Mongolia Agricultural University [30960246, 31260538], Roslin Institute, University of Edinburgh and Biotechnology, Biological Sciences Research Council, UK (BBSRC) [BB/1025360/1, BB/I025328/1], Institute Strategic Programme, National Capability Grants, Roslin Foundation, Scottish Government, UK, Department for Environment, Food and Rural Affairs/Higher Education Funding Council/Scottish Higher Education Funding Council Veterinary Training and Research Initiative, UK, USDA-ARS, USA, USDA-National Research Initiative Competitive Grants Program, USA [2008-03923, 2009-03305], Wellcome Trust [WT095908, WT098051], BBSRC [BB/I025506/1, BB/I025360/1], USDA-NRSP-8, USA, USDA-ARS [5348-32000-031-00D], Meat and Livestock Australia, Australian Wool Innovation Limited through SheepGENOMICS, Australia, Australian Government International Science Linkages Grant, Australia [CG090143], University of Sydney, Australia, CSIRO, Australia, AgResearch, NZ, Beef + Lamb NZ through Ovita, New Zealand, INRA, France, Agence Nationale de la Recherche project SheepSNPQTL, France, European Union through the Seventh Framework Programme Quantomics project [KBBE222664], 3SR project [KBBE245140], Ole Romer grant from Danish Natural Science Research Council, BGI-Shenzhen, China, Earmarked Fund for Modern China Wool & Cashmere Technology Research System [nycytx-40-3], Australian Department of Agriculture Food and Fisheries, Filling the Research Gap project, 'Host control of methane emissions', European Project: 222664,EC:FP7:KBBE,FP7-KBBE-2007-2A,QUANTOMICS(2009), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT), Kunming Institute of Zoology (KIZ), The Roslin Institute, Biotechnology and Biological Sciences Research Council (BBSRC)
Rok vydání: 2014
Předmět:
Zdroj: Science
Science, American Association for the Advancement of Science, 2014, 344 (6188), pp.1168-1173. ⟨10.1126/science.1252806⟩
Science, 2014, 344 (6188), pp.1168-1173. ⟨10.1126/science.1252806⟩
ISSN: 1095-9203
0036-8075
DOI: 10.1126/science.1252806
Popis: International audience; Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.
Databáze: OpenAIRE
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