Ageing and the natural history of dry eye disease: A prospective registry-based cross-sectional study
| Autor: | Ji Soo Kim, Jennifer P. Craig, Michael T.M. Wang, Alex Muntz, Lucas Figueiredo Lacerda, Joevy Lim, Aditya Arora |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Population ageing Pediatrics medicine.medical_specialty Aging Cross-sectional study Meibomian gland Disease Natural history of disease 03 medical and health sciences Young Adult 0302 clinical medicine Epidemiology medicine Humans Registries Young adult business.industry Meibomian Glands Middle Aged eye diseases Natural history Ophthalmology 030104 developmental biology medicine.anatomical_structure Cross-Sectional Studies Tears 030221 ophthalmology & optometry Dry Eye Syndromes Female sense organs business |
| Zdroj: | The ocular surface. 18(4) |
| ISSN: | 1937-5913 |
| Popis: | Purpose To investigate the impact of ageing on ocular surface parameters, and empirically determine optimal prognostic cut-off ages for clinical markers of dry eye disease, aqueous tear deficiency, and meibomian gland dysfunction. Methods A total of 1331 community residents (785 females, 546 males; mean ± SD age, 38 ± 19 years) were recruited in a prospective registry-based cross-sectional study. Dry eye symptomology, ocular surface characteristics, and tear film quality were evaluated for each participant within a single clinical session, in accordance with the global consensus recommendations of the TFOS DEWS II reports. Results Multivariate regression analysis demonstrated positive associations between ageing and clinical markers of dry eye disease (all p ≤ 0.001). The Youden-optimal prognostic cut-off ages for signs of meibomian gland dysfunction occurred during the third decade of life (24–29 years); the optimal predictive ages for lid wiper epitheliopathy, tear film instability, hyperosmolarity, and dry eye symptoms occurred during the fourth decade of life (31–38 years); while the optimal prognostic thresholds for signs of aqueous tear deficiency and ocular surface staining occurred in the fifth and sixth decades of life (46–52 years). Conclusions Advancing age is a significant risk factor for dry eye disease, which represents a growing public health concern with the ageing population worldwide. Signs of meibomian gland dysfunction appeared earlier in the natural history of disease progression, and the brief delay prior to the development of other clinical dry eye signs might represent a window of opportunity for preventative interventions in the young adult age group. |
| Databáze: | OpenAIRE |
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