Hallmarks of Aging in the Liver
| Autor: | David G. Le Couteur, Sun Woo Sophie Kang, Glen P Lockwood, Nicholas J. Hunt, Victoria C. Cogger |
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| Rok vydání: | 2019 |
| Předmět: |
Systemic disease
LSEC liver sinusoidal endothelial cell Review Article IL-8 interleukin 8 Biochemistry miR microRNA AMPK 5′ adenosine monophosphate-activated protein kinase 0302 clinical medicine NAD nicotinamide adenine dinucleotide FOXO forkhead box O Structural Biology Hepatocyte αSMA alpha smooth muscle actin 0303 health sciences VEGF vascular endothelial growth factor Phenotype HSC hepatic stellate cell 3. Good health Computer Science Applications Cell biology IL-6 interleukin 6 medicine.anatomical_structure 030220 oncology & carcinogenesis medicine.symptom KC Küpffer cell Biotechnology Senescence NAFLD non-alcoholic fatty liver disease PDGF platelet derived growth factor SIRT1 sirtuin 1 CR caloric restriction lcsh:Biotechnology Biophysics TNFα tumor necrosis factor alpha Inflammation mTOR mammalian target of rapamycin Nutrient sensing Biology Endothelial 03 medical and health sciences ROS reactive oxygen species Genetic lcsh:TP248.13-248.65 Nutrient sensing pathways Genetics medicine PGC-1α peroxisome proliferator-activated receptor gamma coactivator 1-α 030304 developmental biology NO nitric oxide Epigenome medicine.disease IGF-1 insulin like growth factor 1 Mitochondrial dysfunction Function (biology) |
| Zdroj: | Computational and Structural Biotechnology Journal Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1151-1161 (2019) |
| ISSN: | 2001-0370 |
| Popis: | While the liver demonstrates remarkable resilience during aging, there is growing evidence that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and systemic disease. The aging process in the liver is driven by alterations of the genome and epigenome that contribute to dysregulation of mitochondrial function and nutrient sensing pathways, leading to cellular senescence and low-grade inflammation. These changes promote multiple phenotypic changes in all liver cells (hepatocytes, liver sinusoidal endothelial, hepatic stellate and Küpffer cells) and impairment of hepatic function. In particular, age-related changes in the liver sinusoidal endothelial cells are a significant but under-recognized risk factor for the development of age-related cardiometabolic disease. Graphical Abstract Unlabelled Image Highlights • Liver aging is driven by transcription and metabolic epigenome alterations. • This leads to cellular senescence and low-grade inflammation. • Hepatocyte, sinusoidal endothelial, stellate and Küpffer cells undergoes the hallmarks of aging. • Each cell type demonstrates phenotypical cellular changes with age. |
| Databáze: | OpenAIRE |
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