Protective effect of dexpanthenol against cisplatin‑induced hepatotoxicity
| Autor: | Mehmet Erman Erdemli, Onural Ozhan, Sami Akbulut, Yilmaz Bilgic, Zeynep Aksungur, Nigar Vardi, Hakan Parlakpinar, Yusuf Turkoz |
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| Přispěvatelé: | Bilgic, Y., Department of Gastroenterology, Inonu University Faculty of Medicine, Malatya, 44280, Turkey -- Akbulut, S., Department of Surgery, Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya, 44280, Turkey -- Aksungur, Z., Department of Biochemistry, Inonu University Faculty of Medicine, Malatya, 44280, Turkey -- Erdemli, M.E., Department of Biochemistry, Nigde Omer Halisdemir University, Faculty of Medicine, Nigde, 51240, Turkey -- Ozhan, O., Department of Pharmacology, Inonu University Faculty of Medicine, Malatya, 44280, Turkey -- Parlakpinar, H., Department of Pharmacology, Inonu University Faculty of Medicine, Malatya, 44280, Turkey -- Vardi, N., Department of Embryology and Histology, Inonu University Faculty of Medicine, Malatya, 44280, Turkey -- Turkoz, Y., Department of Biochemistry, Inonu University Faculty of Medicine, Malatya, 44280, Turkey, 0-Belirlenecek |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immunology and Microbiology (miscellaneous) Internal medicine medicine Cisplatin Oncogene Glycogen Chemistry Hepatotoxicity Kupffer cell Articles General Medicine Glutathione Molecular medicine Antioxidant potential 030104 developmental biology medicine.anatomical_structure Endocrinology Apoptosis 030220 oncology & carcinogenesis Dexpanthenol medicine.drug |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2018.6683 |
| Popis: | The aim of the present study was to investigate the protective effect of dexpanthenol (Dexp) against cisplatin (Cis)-induced hepatotoxicity. Thirty-two Sprague Dawley rats were divided into four groups: Control group (n=8), Dexp group (n=8, 500 mg/kg/ip/daily single dose/3 days Dexp), Cis group (n=8, 7 mg/kg/ip/single dose Cis) and Cis+Dexp group (n=8, 500 mg/kg/ip/daily single dose/3 days Dexp +7 mg/kg/ip/single dose Cis). MDA, CAT, GSH, GSH-Px, TOS, TAS, OSI, Total Nitrit, IL-1ß, IL-6 and TNF-? levels were analyzed in liver tissue samples. After paraffinization of liver tissue samples, histopathological (congestion, loss of glycogen, number of Kupffer cells) and immunohistochemical (caspase-3 expression) parameters were assessed on the paraffinized liver sections. GSH, TAS, TOS, OSI, Tot Nit, L-Arginine, ADMA and SDMA levels were measured in the serum samples. Statistically significant differences were found between the groups in terms of all liver tissue biochemical parameters, with the exception of IL-1ß and TNF-? levels. GSH, CAT, GSH-Px, TAS and Tot Nit levels were significantly higher in the Cis+Dexp group compared to the Cis group, whereas MDA, TOS, OSI and IL-6 levels were higher in the Cis group. Similarly, serum GSH, TAS, Tot Nit levels were higher in the Cis+Dexp group whereas TOS, L-Arginine, ADMA and SDMA levels were higher in Cis group. There were statistically significant differences between Control and Cis groups in terms of congestion increase, increase of glycogen loss, increase of Kupffer cell number and increase of caspase-3 expression (P Firat University Scientific Research Projects Management Unit Firat University Scientific Research Projects Management Unit University Faculty of Medicine Animal Research Ethics Committee (2016/A-36). It was funded by Inonu University Scientific Research Project Coordination Unit (Project no. 2016/179). The present study was supported by the Inonu University Scientific Research Project Coordination Unit (grant no. 2016/179). |
| Databáze: | OpenAIRE |
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