The Impact of the Ca
| Autor: | Sasanka Ramanadham, Xiaoyong Lei, Ying Gai Tusing, Tayleur D. White, Abdulaziz Almutairi |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Programmed cell death lcsh:QR1-502 iPLA2β Inflammation Context (language use) Review Phospholipase Biochemistry eicosanoids lcsh:Microbiology resolvins Group VI Phospholipases A2 03 medical and health sciences 0302 clinical medicine Immune system Medicine Animals Humans Lymphocytes Molecular Biology Periodontitis business.industry Cell growth T-cells Macrophages Cancer medicine.disease Immunity Innate 030104 developmental biology 030220 oncology & carcinogenesis Immunology medicine.symptom business |
| Zdroj: | Biomolecules, Vol 11, Iss 577, p 577 (2021) Biomolecules |
| ISSN: | 2218-273X |
| Popis: | The Ca2+-independent phospholipase A2β (iPLA2β) is a member of the PLA2 family that has been proposed to have roles in multiple biological processes including membrane remodeling, cell proliferation, bone formation, male fertility, cell death, and signaling. Such involvement has led to the identification of iPLA2β activation in several diseases such as cancer, cardiovascular abnormalities, glaucoma, periodontitis, neurological disorders, diabetes, and other metabolic disorders. More recently, there has been heightened interest in the role that iPLA2β plays in promoting inflammation. Recognizing the potential contribution of iPLA2β in the development of autoimmune diseases, we review this issue in the context of an iPLA2β link with macrophages and T-cells. |
| Databáze: | OpenAIRE |
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