Pathological changes during aging in barrier-reared Fischer 344 male rats
| Autor: | Sumner J. Foster, Albert M. Jonas, Gerald L. Coleman, G. W. Osbaldiston, Stephen W. Barthold |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Aging Globulin Adenoma Respiratory System medicine.disease_cause Kidney Cardiovascular System Behavioral and Social Sciences chemistry.chemical_compound Testicular Neoplasms Internal medicine Alpha-Globulins Testis medicine Chronic Progressive Nephropathy Animals Germ-Free Life Pituitary Neoplasms Pathological Serum Albumin Specific-pathogen-free Adenoma Chromophobe biology Cholesterol Rats Inbred Strains Mycoplasma Blood Proteins medicine.disease Rats Inbred F344 Rats Specific Pathogen-Free Organisms Endocrinology chemistry Leukemia Myeloid Mycoplasma pulmonis biology.protein Kidney Diseases Spleen Leydig Cell Tumor |
| Zdroj: | Journal of Gerontology |
| ISSN: | 0022-1422 |
| Popis: | Pathology, microbiology, and selected serum chemistries were evaluated in 144 male Fischer rats from 4 to 33 mo of age. The rats were reared and maintained under barrier conditions, which successfully excluded the introduction of major infectious disease agents throughout the entire study, including Mycoplasma pulmonis. A wide variety of pathology was found and tabulated, and many lesions were found to increase in severity and incidence with age. There was a high correlation of renal disease severity with increasing age. Serum total protein and albumin decreased with age, while alpha-1 globulin and cholesterol increased. |
| Databáze: | OpenAIRE |
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