Heterogeneity of CEACAM5 in breast cancer
| Autor: | Victoria L Codony, Jiyoung Kim, Andreas Vincent Brydholm, René Villadsen, Marc Baker Bechmann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.drug_class medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer CEA Invasion medicine CEACAM5 Lymph node Survival analysis business.industry medicine.disease invasion Primary tumor Immunohistochemistry 030104 developmental biology medicine.anatomical_structure Oncology Estrogen 030220 oncology & carcinogenesis immunohistochemistry Cancer research Carcinogenesis business Cohort study Research Paper |
| Zdroj: | Bechmann, M B, Brydholm, A V, Codony, V L, Kim, J & Villadsen, R 2020, ' Heterogeneity of CEACAM5 in breast cancer ', OncoTarget, vol. 11, no. 43, pp. 3886-3899 . https://doi.org/10.18632/oncotarget.27778 Oncotarget |
| DOI: | 10.18632/oncotarget.27778 |
| Popis: | CEACAM5 is overexpressed in many primary breast carcinomas. However, the exact role of CEACAM5 in breast cancer tumorigenesis remains unresolved. Here, we examined a repository of 110 cryopreserved primary breast carcinomas by immunohistochemistry to assess the distribution of CEACAM5 in tumor subtypes. The majority of estrogen receptor-positive and HER2-overexpressing tumors were CEACAM5-positive, whereas most of Triple-negative tumors were negative. Assessing sample sets of paired primary breast cancers and corresponding lymph node lesions from a total of 59 patients revealed a high correlation between primary tumor and lymph node with regard to CEACAM5-status. However, a notable subset of sample sets demonstrated intratumoral heterogeneity in the primary tumor, the metastatic lesion or both, suggesting that both CEACAM5-positive and –negative cells can play a role in tumor dissemination. When examining the consequence of expression of CEACAM5 in breast cancer cell lines in culture assays we found that CEACAM5-expressing cells were less invasive. In survival analysis, using cohort studies of breast cancer, expression of CEACAM5 predicted different clinical outcomes depending on molecular subtypes. Altogether, our analysis suggests that CEACAM5 plays a context-dependent role in breast cancer that warrants further investigation. |
| Databáze: | OpenAIRE |
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