Fluid Resuscitation With Lactated Ringer's Solution Versus Normal Saline in Acute Pancreatitis

Autor:	Chia Siang, Kow, Ismail Abdul Sattar, Burud, Syed Shahzad, Hasan
Rok vydání:	2022
Předmět:	Ringer's Lactate Endocrinology Pancreatitis Hepatology Endocrinology Diabetes and Metabolism Acute Disease Internal Medicine Humans Saline Solution Isotonic Solutions Randomized Controlled Trials as Topic
Zdroj:	Pancreas. 51:752-755
ISSN:	1536-4828 0885-3177
Popis:	We aimed to perform a systematic review and meta-analysis of randomized controlled trials to summarize the overall association between the choice of fluid (lactated Ringer's [LR] or normal saline [NS]) and clinical outcomes in patients with acute pancreatitis.A systematic literature search was performed in electronic databases to identify eligible randomized controlled trials. Meta-analyses with the random-effects and IVhet models were used to estimate the pooled odds ratio (OR) for outcomes of interest with the administration of LR relative to NS, at 95% confidence intervals (CIs).There was a significant reduction in the odds of intensive care unit admission and development of local complications, respectively, with the administration of LR among hospitalized patients with acute pancreatitis relative to administration of NS (pooled ORs, 0.33 [95% CI, 0.13-0.81] and 0.43 [95% CI, 0.21-0.89], respectively).Our findings are able to assist clinicians in the navigation of the proper choice of fluid in patients with acute pancreatitis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf386f775ffd7822db9b904f6010f50 https://doi.org/10.1097/mpa.0000000000002112 Zobrazit plný text záznamu